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LC-ESI-MS determination of quassinoids isobrucein B and neosergeolide in Picrolemma sprucei stem infusions
Infusoes dos caules de Picrolemma sprucei (pseudonimo: P. pseudocoffea) sao principalmente utilizadas como antimalaricos em toda regiao amazonica. Desta especie foram isolados os quassinoides… Expand
Chemical composition, ethnopharmacology and biological activity of Geissospermum Allemão species (Apocynaceae Juss.)
- M. S. Vital, Ana Lúcia Basílio Carneiro, L. F. R. Silva, Rodrigo C. N. Amorim, Marlene Rodrigues Marcelino Camargo, A. M. Pohlit
The chemistry and pharmacology literature on Geissospermum is surveyed. Pau-pereira or pao pereira ( G. laeve (Vell.) Miers; G. vellosii Fr. All. is a synonym) is the best known of approximately six… Expand
Gram-scale isolation of isobrucein B and neosergeolide from Picrolemma sprucei Hook. f.
This paper describes a method for obtaining grams of these quassinoids whose purification relies only on recrystallization and shows that the quantities obtained in previous extraction processes have been shown to be a limiting factor for continuation of these studies. Expand
Gastro-protective effects of isobrucein B, a quassinoid isolated from Picrolemma sprucei.
IsoB may be a prototypic compound to provide protective effects against NSAID-induced gastritis and possibly other gastropathies and may be due to a reduction in IL-1β and KC/CXCL1 production/release and leukocyte rolling, adhesion and migration. Expand
Antimalarial Activities of Seaweeds Spatoglossum schroederi, Gracilaria birdiae and Udotea flabellum from Rio Grande do Norte Coast, Brazil
- G. Dantas, H. Rocha, Rodrigo C. N. Amorim, L. F. R. Silva, A. M. Pohlit, V. Andrade-Neto
- 31 December 2015
Data showed that the present bioactive components in these algae can be promising for the development of new antimalarial drugs; attempt to purify these compounds are in progress for furtherbiological assays. Expand
Biological activity and quassinoid content of fruits from the amazonian medicinal plant Picrolemma sprucei ( Simaroubaceae )
Picrolemma sprucei Hook. f. (Simaroubaceae) is a medicinal plant that is used throughout the Amazon region in the treatment of malaria. No previous report has been published on the biological… Expand