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- Simone Molz, Helena Decker, +4 authors Carla Inês Tasca
- Neurochemical Research
- 2007
Glutamate excitotoxicity may culminate with neuronal and glial cell death. Glutamate induces apoptosis in vivo and in cell cultures. However, glutamate-induced apoptosis and the signaling pathways… (More)
- Jeferson LuÃs Franco, Hugo Braga, +8 authors Marcelo Farina
- Chemical research in toxicology
- 2007
Plants of the genus Polygala have been shown to possess protective effects against neuronal death and cognitive impairments in neurodegenerative disorders related to excitotoxicity. Moreover,… (More)
- Jeferson LuÃs Franco, ThaÃs Posser, +8 authors Alcir Luiz Dafre
- Toxicology letters
- 2009
Malathion toxicity has been related to the inhibition of acetylcholinesterase and induction of oxidative stress, while zinc has been shown to possess neuroprotective effects in experimental and… (More)
- Fabiano Mendes de Cordova, Ana Lúcia S Rodrigues, +4 authors Rodrigo Bainy Leal
- Brain research
- 2004
Lead (Pb(2+)) is widely recognized as a neurotoxicant whose mechanisms of action are not completely established. We have previously demonstrated that Pb(2+) can activate the p38(MAPK) pathway and… (More)
- ThaÃs Posser, Jeferson LuÃs Franco, Larisa Bobrovskaya, Rodrigo Bainy Leal, Phillip W. Dickson, Peter Dunkley
- Journal of neurochemistry
- 2009
Manganese (Mn2+) is an essential metal involved in normal functioning of a range of physiological processes. However,occupational overexposure to Mn2+ causes neurotoxicity. The dopaminergic system is… (More)
- Luciana Teixeira Zimmermann, Danúbia Bonfanti dos Santos, +6 authors Marcelo Farina
- Neurotoxicology
- 2013
Various forms of mercury possess different rates of absorption, metabolism and excretion, and consequently, toxicity. Methylmercury (MeHg) is a highly neurotoxic organic mercurial. Human exposure is… (More)
- Fabiano Mendes de Cordova, Aderbal Silva Aguiar, +10 authors Rodrigo Bainy Leal
- PloS one
- 2012
Manganese (Mn) is an essential metal for development and metabolism. However, exposures to high Mn levels may be toxic, especially to the central nervous system (CNS). Neurotoxicity is commonly due… (More)
Diphenyl diselenide confers neuroprotection against hydrogen peroxide toxicity in hippocampal slices
- ThaÃs Posser, Jeferson LuÃs Franco, Daiane Almeida dos Santos, Ana Paula Rigon, Rodrigo Bainy Leal
- Brain Research
- 2008
The present study aimed at investigating the potential in vitro protective effect of the organochalcogenide diphenyl diselenide - (PhSe)2 - against hydrogen peroxide (H2O2)-induced toxicity in rat… (More)
- Rodrigo Bainy Leal, Sandro José Ribeiro, +4 authors Afonso Celso Dias Bainy
- Aquatic toxicology
- 2006
Lead (Pb2+) is a neurotoxic trace metal, widespread in aquatic environment that can change physiologic, biochemical and behavioral parameters in diverse fish species. Chemical exposure may drive… (More)
- Jader Nones, Ana Paula Ramos Costa, Rodrigo Bainy Leal, Flávia Carvalho Alcântara Gomes, Andréa Gonçalves Trentin
- Cell and Tissue Research
- 2012
The neural crest (NC) corresponds to a collection of multipotent and oligopotent progenitors endowed with both neural and mesenchymal potentials. The derivatives of the NC at trunk level include… (More)