Rodrigo Assar

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Calcium/calmodulin-dependent protein kinase IV (CaMKIV) plays a key role in the regulation of calcium-dependent gene expression. The expression of CaMKIV and the activation of CREB regulated genes are involved in memory and neuronal survival. We report here that: (a) a bioinformatic analysis of 15,476 promoters of the human genome predicted several Wnt(More)
BACKGROUND The importance of in silico predictions for understanding cellular processes is now widely accepted, and a variety of algorithms useful for studying different biological features have been designed. In particular, the prediction of cis regulatory modules in non-coding human genome regions represents a major challenge for understanding gene(More)
Mathematical models of wine fermentation kinetics promise early diagnosis of stuck or sluggish winemaking processes as well as better matching of industrial yeast strains to specific vineyards. The economic impact of these challenges is significant: worldwide losses from stuck or sluggish fermentations are estimated at 7 billion A C annually, and yeast(More)
  • Jo Richardson, Anton Gauert, Luis Briones Montecinos, Lucía Fanlo, Zainalabdeen Mohmammed Alhashem, Rodrigo Assar +4 others
  • 2016
Collective cell migration is fundamental for life and a hallmark of cancer. Neural crest (NC) cells migrate collectively, but the mechanisms governing this process remain controversial. Previous analyses in Xenopus indicate that cranial NC (CNC) cells are a homogeneous population relying on cell-cell interactions for directional migration, while chick(More)
In order to describe the dynamic behavior of a complex biological system, it is useful to combine models integrating processes at different levels and with temporal dependencies. Such combinations are necessary for modeling acclimatization, a phenomenon where changes in environmental conditions can induce drastic changes in the behavior of a biological(More)
In order to treat osteoporosis and other bone mass disorders it is necessary to understand the regulatory processes that control the cell fate decisions responsible for going from bone precursor cells to bone tissue. Many processes interact to regulate cell division, differentiation and apoptosis. There are models for these basic processes, but not for(More)
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