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Call centers usually handle several types of calls, but it usually is not possible or cost-effective to have every agent be able to handle every type of call. Thus, the agents tend to have different skills, in different combinations. In such an environment, it is challenging to route calls effectively and determine the staff requirements. This paper(More)
Prognostic factors for mortality and recurrent hemorrhage in the preoperative, 2-week period were determined in 1114 patients who participated in the antifibrinolytic therapy investigations of the Cooperative Aneurysm Study between 1970 and 1977. Factors significantly related to mortality were admission neurological status, diastolic blood pressure,(More)
Tumour necrosis factor (TNF) was found originally in mouse serum after intravenous injection of bacterial endotoxin into mice primed with viable Mycobacterium bovis, strain Bacillus Calmette-Guerin (BCG). TNF-containing serum from mice is cytotoxic or cytostatic to a number of mouse and human transformed cell lines, but less or not toxic to normal cells in(More)
A deficiency in the plasma protease inhibitor alpha 1-antitrypsin can cause chronic obstructive emphysema or infantile liver cirrhosis. This deficiency results from a single amino acid substitution created by a G to A transition in the gene for alpha 1-antitrypsin. Chemically synthesized specific oligonucleotide probes (19-mer) have been used to develop a(More)
The rat serum albumin gene has been isolated from a recombinant library containing the entire rat genome cloned in the lambda phage Charon 4A. Preliminary R-loop and restriction analysis has revealed that this gene is split into at least 14 fragments (exons) by 13 intervening sequences (introns), and that it occupies a minimum of 14.5 kilobases of genomic(More)
This review of the literature on aging and the central nervous system attempts to cover the basic perameters investigated at both human and infrahuman levels for the better part of the last century. The results have indicated that there is a rather considerable lack of consistency in the data both within the frame of reference of a single species, and with(More)
Call centers usually handle several types of calls. To do so effectively, agents are given special training. However, it is often not cost-effective to have every agent be able to handle every type of call. Thus, the agents tend to have different skills, in different combinations. Call centers are equipped with automatic call distributors to assign calls to(More)
This study presents general observations of neurological examination in rats after various CNS manipulations. The examination consisted of neurologic reactions as described in Bures and co-workers. Subjects studied were controls, hippocampal irradiates, and animals with cerebellar lesions or midline cerebellar transplants. Utility of the procedure as an(More)
This Internet Supplement provides material omitted from the main paper. In particular, additional details are provided for the three simulation experiments in Sections 4, 6 and 7 in the main paper. Abstract in Main Paper Call centers usually handle several types of calls, but it usually is not possible or cost-effective to have every agent be able to handle(More)
The study of mitochondrial biogenesis has been greatly advanced by the isolation and characterization of various mutants of mitochondrial function. Genetic analysis of such mutants led to the demonstration of non-Mendelian inheritance and of re-combination of cytoplasmic genetic characteristics which are considered to reside on mitochondrial DNA (mtDNA)(More)