Rodman Morgan

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End-to-end associations of metaphase chromosomes have been observed in a variety of human tumors, ageing cells, and several chromosome instability syndromes. Since telomeres of tumor cells and ageing tissues are often reduced in length, it has been suggested that chromosome end associations may be due to loss of telomeric repeats. We report the molecular(More)
PURPOSE Minority accrual onto clinical trials is of significant interest to cooperative oncology study groups. The Eastern Cooperative Oncology Group (ECOG) conducted a study to identify barriers and solutions to African American accrual onto clinical trials. METHODS We hypothesize that the National Medical Association (NMA) might provide insight into(More)
A new cell line, SUP-HD1 , was established from the pleural effusion of a patient with nodular sclerosing Hodgkin’s disease (NSHD). The SUP-HD1 cells had the characteristic morphology of Reed-Sternberg cells and contained acid phosphatase and nonspecific esterase. The cells lacked the Epstein-Barr virus (EBV) genome and reacted with monoclonal antibodies(More)
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9531 Background: Genetic manipulation of T cells may provide promising new therapies for pediatric solid tumors. T cells can be modified to express chimeric antigen receptors (CAR), which link the antigen-recognition region of an antibody to a CD3-zeta signaling domain and various costimulatory domains. CARs allow for non-MHC-restricted tumor recognition,(More)
The Philadelphia (Ph) chromosome translocation which is classically observed in chronic myeloid leukemia ((.'Ml,) is sporadically found in acute lymphoblastic leukemia (ALL). In CML the translocation break point on chromosome 22 is within the breakpoint cluster region, while in childhood ALL, no detectable change in breakpoint cluster region is routinely(More)
A woman was found to have 42 autosomes due to engagement of both chromosomes 14 in Robertsonian rearrangements, one with a chromosome 21 and the other with a chromosome 22: t(14q21q) and t(14q22q). The two translocations appear monocentric and by silver staining have no rRNA activity. The t(14q21q) translocation is familial and was ascertained through a(More)
Telomeric fusion, a rare phenomenon, was observed in malignant cells from the peripheral blood of an 18-year-old male with rapidly progressive pre-T-cell acute lymphoblastic leukemia (ALL). Only two comparable cases, both with B-cell ALL, have been reported with telomeric fusion in neoplasia. All of the leukemic cells examined from our patient had two(More)
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