Rodion N Stepanenko

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Two new triterpenoid saponins 1 and 2 were isolated from the methanol extract of the roots of Acanthophyllum gypsophiloides Regel. These saponins have quillaic acid or gypsogenin moieties as an aglycon, and both bear similar sets of two oligosaccharide chains, which are 3-O-linked to the triterpenoid part trisaccharide(More)
Forty patients with a verified diagnosis of multiple sclerosis (MS), the majority of whom had the secondary progressive form of the disease, received a short-term treatment with myelopid (MP). After this 10 patients were given a long-term treatment with MP. The clinical trial was carried out by the double blind method using placebo. The patients' status was(More)
A complex immunotherapy regimen containing myelopid in combination with chemotherapeutic drugs was prescribed for 30 patients aged from 17 to 54 years and suffering from destructive pulmonary tuberculosis. It was proved that a complex treatment favored the normalization of the main immunologic indices, thus greatly increasing the efficacy of pulmonary(More)
298 Specific stimulation of the immune system against tumor antigens, which may result in elimination of malignant cells, may be performed with the use of vaccines containing a specific native or synthetic tumorassociated antigen. To develop a prototype antitumor vaccine, we synthesized an oligosaccharide fragment of tumor-associated antigen, obtained its(More)
The study of mediators determining functioning of the immune system is currently receiving much attention. Some of these mediators, such as interleukins [8, 9], 7-interferon [15], macrophage migration inhibition factor [13], growth factors of T and B cells [ii, 14], etc., are produced by immunocompetent cells after introduction of an antigen into the body(More)
The effect of a new immunocorrecting preparation, Myelopid, on the antibody-forming cell content of mouse spleen after gamma-irradiation (1-3 Gy) has been investigated. The preparation administered after immunization of mice with sheep erythrocytes increases the number of antibody-forming cells in the spleen, the effect being a function of radiation dose(More)
The effect of myelopid (MP) on the in vitro antibody production in man in norm and secondary postoperative immunodeficiency state, as well as the effect of immunocorrection therapy with MP on PWM-induced antibody production in LPB cultures during postoperative period have been studied. A stimulating effect of MP on IgA and IgM production in LPB cultures on(More)