Rodger F. Henry

Tino Dyhring1
William H Bunnelle1
Diana Donnelly-Roberts1
Karin R Tietje1
Peter Curzon1
1Tino Dyhring
1William H Bunnelle
1Diana Donnelly-Roberts
1Karin R Tietje
1Peter Curzon
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A novel 4-aminocyclopentapyrrolidine series of N-type Ca(2+) channel blockers have been discovered. Enantioselective synthesis of the 4-aminocyclopentapyrrolidines was enabled using N-tert-butyl sulfinamide chemistry. SAR studies demonstrate selectivity over L-type Ca(2+) channels. N-type Ca(2+) channel blockade was confirmed using electrophysiological(More)
A series of potent neuronal nicotinic acetylcholine receptor (nAChR) ligands based on a 3,8-diazabicyclo[4.2.0]octane core have been synthesized and evaluated for affinity and agonist efficacy at the human high affinity nicotine recognition site (halpha4beta2) and in a rat model of persistent nociceptive pain (formalin model). Numerous analogs in this(More)
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