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BACKGROUND Interleukin 13 (IL13) is a T-helper type 2 (Th2) cytokine associated with inflammation and pathology in allergic diseases such as bronchial asthma. We have shown that treatment with lebrikizumab, an anti-IL13 monoclonal antibody, significantly improves prebronchodilator forced expiratory volume in 1 s (FEV(1)) in a subset of subjects with(More)
Pulmonary hemorrhage is a rare and often fatal complication of systemic lupus erythematosus (SLE). Treatment with high-dose steroids and cyclophosphamide has been of only modest value, with a reported mortality of up to 92%. We have recently seen three patients with active SLE who developed acute life-threatening pulmonary hemorrhage. Diagnostic evaluation(More)
It is becoming increasingly important that communication protocols be formally specified and verified. This paper describes a particular approach–the state transition model–using a collection of mechanically supported specification and verification tools incorporated in a running system called AFFIRM. Although developed for the specification of(More)
The n Extra Element Theorem (n EET) is an extension of Middlebrook's Extra Element Theorem, to the case when multiple extra elements are added simultaneously to a circuit. Its major application is to write transfer functions directly as rational fractions, without need to perform loop an node analysis and algebraic manipulations. This is accomplished by(More)
That viral encephalitis can produce daytime hypoventilation is well appreciated, but an association of this infection with the development of a prolonged disturbance of breathing during sleep once the ventilatory disorder during wakefulness has resolved, has not been reported. We describe a young male who required assisted mechanical ventilation in(More)