Rod H. Smallwood

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We have developed a new computational modelling paradigm for predicting the emergent behaviour resulting from the interaction of cells in epithelial tissue. As proof-of-concept, an agent-based model, in which there is a one-to-one correspondence between biological cells and software agents, has been coupled to a simple physical model. Behaviour of the(More)
The electrical resistivity of mammalian tissues varies widely and is correlated with physiological function. Electrical impedance tomography (EIT) can be used to probe such variations in vivo, and offers a non-invasive means of imaging the internal conductivity distribution of the human body. But the computational complexity of EIT has severe practical(More)
Computational modeling of biological systems, or in silico biology, is an emerging tool for understanding structure and order in biological tissues. Computational models of the behavior of epithelial cells in monolayer cell culture have been developed and used to predict the healing characteristics of scratch wounds made to urothelial cell cultures(More)
The inherent complexity of biomedical systems is well recognized; they are multiscale, multiscience systems, bridging a wide range of temporal and spatial scales. While the importance of multiscale modelling in this context is increasingly recognized, there is little underpinning literature on the methodology and generic description of the process. The(More)
Electrical recordings have been made from cutaneous electrodes placed on the trunk with a view to establishing the source of the slow potential changes which can be recorded. Cutaneous recordings have been made on 16 normal subjects in both the fasted and fed states, and in some cases simultaneous recordings have been made from electrodes attached to the(More)
BACKGROUND When an electrical potential is applied to human tissue, the pattern of the resulting current flow is determined by the shapes, arrangements, and internal structure of the tissue cells. By measurement of the electrical current patterns over a range of frequencies, and use of an inverse modelling procedure, electrical variables describing the(More)
A semiclosed loop, bedside insulin infusion system using a simple basal infusion algorithm consisting of a linear transition between two insulin delivery rates as blood glucose (BG) increases has been developed. A theoretical study using computer simulation has now been undertaken to examine the effect of BG sampling frequency and algorithm parameters on BG(More)
This paper describes the Sheffield Mk3.5 EIT/EIS system which measures both the real and imaginary part of impedance at 30 frequencies between 2 kHz and 1.6 MHz. The system uses eight electrodes with an adjacent drive/receive electrode data acquisition protocol. The system is modular, containing eight identical data acquisition boards, which contain DSPs to(More)
The aim of the Epitheliome Project is to develop a computational model of cell behaviour within the context of tissue architecture, differentiation, wound repair and malignancy. Integration is central to tissue development for skin, integration between mesenchymal and epithelial tissue; at the physical level from focal adhesions and adherens junctions to(More)
The measurement of evaporative water loss from the skin, using a ventilated chamber, usually requires two high-accuracy devices for the measurement of the inflow and outflow relative humidity. The water-loss rate is proportional to the difference between the inflow and outflow relative humidity, and a sensor with low absolute accuracy can be used if the(More)