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Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity)
TLDR
In vitro experiments showed that the Mumijo extract caused in cortical neurons a strong neuroprotective effect against the apoptosis-inducing amyloid peptide fragment β-fragment 25–35 (Aβ25–35).
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Structure and Configuration of Phosphoeleganin, a Protein Tyrosine Phosphatase 1B Inhibitor from the Mediterranean Ascidian Sidnyum elegans.
TLDR
A new phosphorylated polyketide, phosphoeleganin, has been isolated from the Mediterranean ascidian Sidnyum elegans and inhibited the protein tyrosine phosphatase 1B (PTP1B) activity.
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P2X7 antagonists for CNS indications: recent patent disclosures.
TLDR
This patent review aims at analyzing the recent patent literature with a particular emphasis on those patents that are thought to deal with CNS penetrant compounds on the basis of their physicochemical features, the assays described in the patents and the uses these compounds are claimed for.
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Conithiaquinones A and B, Tetracyclic Cytotoxic Meroterpenes from the Mediterranean Ascidian Aplidium conicum
Chemical investigation of the Mediterranean ascidian A. conicum resulted in the isolation of two new meroterpenes, the conithiaquinones A (1) and B (2), in addition to two previously reported…
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Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine
TLDR
An exhaustive exploration into the metabolic content of the Mediterranean sponge Axinella-polypoides resulted in the isolation of the new betaine 5 and the new cyclonucleoside 8, providing evidence that the sponge does not elaborate pyrrole-imidazole alkaloids (PIAs) but, interestingly, it was shown to contain two already known cyclodipeptides, compounds 9 (verpacamide A) and 10.
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Long-Lived Phonon Polaritons in Hyperbolic Materials.
Natural hyperbolic materials with dielectric permittivities of opposite signs along different principal axes can confine long-wavelength electromagnetic waves down to the nanoscale, well below the…
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Terahertz response of monolayer and few-layer WTe2 at the nanoscale
TLDR
Data for microcrystals up to 12 layers thick reveal how the response of a few-layer WTe2 asymptotically approaches the bulk limit in the THz range confined to trilayer terraces.
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Aplisulfamines, New Sulfoxide-Containing Metabolites from an Aplidium Tunicate: Absolute Stereochemistry at Chiral Sulfur and Carbon Atoms Assigned Through an Original Combination of Spectroscopic…
Two new sulfoxide-containing metabolites, aplisulfamines A (1) and B (2), have been isolated from an Aplidium sp. collected in the Bay of Naples. Their planar structure and geometry of a double bond…
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Polyaxibetaine, an amino acid derivative from the marine sponge Axinella polypoides.
A new pyridinium derivative, polyaxibetaine (3), has been isolated from the marine sponge Axinella polypoides, together with two known modified amino acids, 1 and 2. The planar structure of compound…
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Zorrimidazolone, a Bioactive Alkaloid from the Non-Indigenous Mediterranean Stolidobranch Polyandrocarpa zorritensis
TLDR
Zorrimidazolone showed a modest cytotoxic activity against C6 rat glioma cell line and has been elucidated by spectroscopic analysis and bioactivity of all compounds has been investigated.
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