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OBJECTIVE To compare a practice of protocol-directed sedation during mechanical ventilation implemented by nurses with traditional non-protocol-directed sedation administration. DESIGN Randomized, controlled clinical trial. SETTING Medical intensive care unit (19 beds) in an urban teaching hospital. PATIENTS Patients requiring mechanical ventilation(More)
STUDY OBJECTIVE To determine whether the use of continuous i.v. sedation is associated with prolongation of the duration of mechanical ventilation. DESIGN Prospective observational cohort study. SETTING The medical ICU of Barnes-Jewish Hospital, a university-affiliated urban teaching hospital. PATIENTS Two hundred forty-two consecutive ICU patients(More)
BACKGROUND This study sought to compare 2 strategies for the administration of enteral feeding to mechanically ventilated medical patients. METHODS The prospective, controlled, clinical trial was carried out in a medical intensive care unit (19 beds) in a university-affiliated, urban teaching hospital. Between May 1999 and December 2000, 150 patients were(More)
OBJECTIVE To evaluate a clinical guideline for the treatment of ventilator-associated pneumonia. DESIGN Prospective before-and-after study design. SETTING A medical intensive care unit from a university-affiliated, urban teaching hospital. PATIENTS Between April 1999 and January 2000, 102 patients were prospectively evaluated. INTERVENTIONS(More)
BACKGROUND Hospital pharmacists make many recommendations that improve patients' quality of care and/or reduce drug costs. While the impact of quality-of-care interventions is difficult to quantify, those limited to cost savings could be assessed in a prospective, randomized fashion. OBJECTIVE To assess the impact of pharmacist-initiated interventions on(More)
BACKGROUND Translating guidelines into clinical practice has proved to be quite difficult, even when the guidelines are well accepted and noncontroversial. Both computerized reminders and academic detailing have been effective in changing physician prescribing behavior. In this study, we sought to use these methods, mediated by clinical pharmacists, to(More)
OBJECTIVE The purpose of this study was to determine the impact of scheduled changes of antibiotic classes, used for the empirical treatment of suspected or documented Gram-negative bacterial infections, on the occurrence of inadequate antimicrobial treatment of nosocomial infections. DESIGN Prospective observational study. SETTING Medical (19-bed) and(More)
We used computerized alerts to identify patients with elevated troponin levels. In the intervention group, pharmacists performed one-on-one physician education about secondary prevention medications. Control group patients received standard care. The intervention had a significant impact on the proportion of patients discharged on ACE-inhibitors (378/458(More)
Calcium homeostasis and the symptoms, etiology, and general medical management of hypercalcemia are reviewed. Hypercalcemia, an elevation in total serum calcium concentration, may produce neurologic, gastrointestinal, renal, and cardiovascular disturbances; it may also cause calcification in extraskeletal tissue. Hyperparathyroidism and malignancy cause(More)
The objective of this study was to examine the effectiveness of inhaled beclomethasone in the treatment of stable chronic obstructive airway disease (COAD). Eight patients completed a randomized, double-blind, placebo-controlled, crossover trial of inhaled beclomethasone and oral prednisone. Each patient received 3 treatment regimens given for 14 days:(More)