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PURPOSE To determine the safety and efficacy of two docetaxel doublets in hormone-refractory prostate cancer (HRPC) patients and to examine the prognostic role of polymorphisms in host genes important to docetaxel metabolism and transport. EXPERIMENTAL DESIGN Sixty-four chemotherapy-naive patients with HRPC were randomized to docetaxel and vinorelbine (D,(More)
PURPOSE Angiogenesis plays an essential role in tumor development, invasion and metastasis. We evaluated the efficacy and safety of dual angiogenesis blockade with bevacizumab and sorafenib in patients with metastatic breast cancer. PATIENTS AND METHODS Patients who had received no more than 2 prior chemotherapy regimens in any setting were treated with(More)
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