Robin Wuestenberg

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Glioblastoma is the most common malignant brain tumor in adults. The currently available treatments offer only a palliative survival advantage and the need for effective treatments remains an urgent priority. Activation of the p53 growth suppression/apoptotic pathway is one of the promising strategies in targeting glioma cells. We show that the quinoline(More)
The invasion- and apoptosis-associated thromboxane synthase gene encoding an enzyme of the arachidonic acid pathway has been implicated in glioma progression. Furegrelate, a specific inhibitor of thromboxane synthase, blocks cell motility, induces apoptosis and increases sensitivity to drug induced apoptosis in human glioma cells in vitro. The impact of(More)
Results A total of 47 critically ill patients (32 men, mean age 66 ± 9 years, mean SOFA-score on admission 9 ± 3) with Clostridium non-difficile infection were included in this study. The most common pathogens were Clostridium innocum (n = 23), Clostridium perfringens (n = 11), Clostridium tertium (n = 6) and others (n = 7). Pathogens were detected in 62%(More)
With increasing numbers of in vivo experiments in the field of neuroscience, the interest in methods for in vivo imaging of animal brains as small as those of mice has increased. Because highly specialized small bore scanners with high field strengths are not commonly available, clinical magnetic resonance imaging (cMRI) scanners have been used in the past(More)
Results Two hundred eleven ICU patients had liver cirrhosis (12%). Admissionand peak DIC score within 48 hours from ICU admission differed significantly between patient with and without cirrhosis. Significant differences between patients with and without cirrhosis were observed in platelet count (PLT), fibrinogen and prothrombin time (PT), activated Partial(More)
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