Robin S Dothager

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Late-stage malignant melanoma is a cancer that is refractory to current chemotherapeutic treatments. The average survival time for patients with such a diagnosis is 6 months. In general, the vast majority of anticancer drugs operate through induction of cell cycle arrest and cell death in either the DNA synthesis (S) or mitosis (M) phase of the cell cycle.(More)
Upon recognition of DNA breaks caused by various genotoxic insults, the enzyme poly(ADP-ribose) polymerase-1 (PARP-1; ADP= adenosine diphosphate) is able to bind damaged DNA and initiate the repair process. Once bound to DNA, PARP-1 is activated and uses b-NAD (NAD= nicotinamide adenine dinucleotide) to poly(ADP-ribosyl)ate proteins such as histones,(More)
As general cytotoxins are still the backbone of anticancer chemotherapy, the identification of selective inducers of cell death in defined cancer types and subtypes is one of the major goals of modern oncology research. Thus, compounds identified with such selectivity have utility as probes of cancer-type-specific biological pathways, and optimized versions(More)
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