Robin S. Dothager

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We compare the folding transition state (TS) of ubiquitin previously identified by using psi analysis to that determined by using analysis. Both methods attempt to identify interactions and their relative populations at the rate-limiting step for folding. The TS ensemble derived from psi analysis has an extensive native-like chain topology, with a(More)
BACKGROUND Positron emission tomography (PET) allows sensitive, non-invasive analysis of the distribution of radiopharmaceutical tracers labeled with positron (β(+))-emitting radionuclides in small animals and humans. Upon β(+) decay, the initial velocity of high-energy β(+) particles can momentarily exceed the speed of light in tissue, producing Cerenkov(More)
Late-stage malignant melanoma is a cancer that is refractory to current chemotherapeutic treatments. The average survival time for patients with such a diagnosis is 6 months. In general, the vast majority of anticancer drugs operate through induction of cell cycle arrest and cell death in either the DNA synthesis (S) or mitosis (M) phase of the cell cycle.(More)
Upon recognition of DNA breaks caused by various geno-toxic insults, the enzyme poly(ADP-ribose) polymerase-1 (PARP-1; ADP = adenosine diphosphate) is able to bind damaged DNA and initiate the repair process. [1] Once bound to DNA, PARP-1 is activated and uses b-NAD + (NAD + = nicotinamide adenine dinucleotide) to poly(ADP-ribosyl)ate proteins such as(More)
As general cytotoxins are still the backbone of anticancer chemotherapy, the identification of selective inducers of cell death in defined cancer types and subtypes is one of the major goals of modern oncology research. Thus, compounds identified with such selectivity have utility as probes of cancer-type-specific biological pathways, and optimized versions(More)
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