Robin McEntire

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This paper describes the design of and experimentation with the Knowledge Query and Manipulation Language (KQML), a new language and protocol for exchanging information and knowledge. This work is part of a larger effort, the ARPA Knowledge Sharing Effort which is aimed at developing techniques and methodology for building large-scale knowledge bases which(More)
The Grid is proposed as the next-generation Web, and will provide the computational power and data management infrastructure necessary to support the collaboration of people, together with data, tools and computational resources [1]. The scientific process is an example of such a collaborative process where Grid technology can facilitate virtual(More)
High-quality annotation of biological data is central to bioinformatics. Annotation using terms from ontologies provides reliable computational access to data. The Gene Ontology (GO), a structured controlled vocabulary of nearly 17,000 terms, is becoming the <i>de facto</i> standard for describing the functionality of gene products. Many prominent(More)
BACKGROUND Understanding the donor base, infectious disease prevalence, and donation loss at various blood donation sites will help maximize blood collection efforts and blood availability. STUDY DESIGN AND METHODS Using donation data collected at five US blood centers, the prevalence of HIV, HTLV, HBsAg, and HCV in first-time whole-blood donations at 10(More)
BACKGROUND Commonly quoted ABO/Rh(D) frequencies in the US are usually from relatively small studies with racial or ethnic categories often judged by name or appearance. STUDY DESIGN AND METHODS A 10-year demographic database that contained racial or ethnic and ABO/Rh(D) phenotype data on 3.1 million allogeneic and autologous donors giving blood at five(More)
BACKGROUND Blood donors with high-risk behaviors may not self-defer because they failed to read or understand the screening educational materials. STUDY DESIGN AND METHODS In 1993, a total of 34,726 allogeneic donors responded to an anonymous mail survey of 50,162 donors that inquired about demographics, donor status, amount of the donor educational(More)
MOTIVATION Protein family databases provide a central focus for scientific communities as well as providing useful resources to aide research. However, such resources require constant curation and often become outdated and discontinued. We have developed an ontology-driven system for capturing and managing protein family data that addresses the problems of(More)
BACKGROUND Blood donations in the United States have been screened for antibody to human T-cell lymphotropic virus types I and II (HTLV-I/II) since November 1988. Although clinically diagnosed illness associated with HTLV-I/II remains relatively uncommon, blood donors notified of HTLV infection frequently report negative psychological and social effects(More)
Ontologies are specifications of the concepts in a given field, and of the relationships among those concepts. The development of ontologies for molecular-biology information and the sharing of those ontologies within the bioinformatics community are central problems in bioinformatics. If the bioinformatics community is to share ontologies effectively,(More)
The Gene Ontology (GO), a structured controlled vocabulary of over 15,000 terms, is becoming the de facto standard for describing gene products in terms of their molecular functions, biological processes in which they participate, and the cellular locations in which they are active. However, current annotation editors do not constrain the choice of GO terms(More)