Robin Elliott

Learn More
Osteoprotegerin-ligand (OPGL) is a key osteoclast differentiation/activation factor essential for bone remodeling. We report that mice lacking OPGL or its receptor RANK fail to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Transplantation and OPGL-rescue experiments in opgl-/- and rank-/- pregnant females showed(More)
RANKL is a TNF family member that mediates osteoclast formation, activation, and survival by activating RANK. The proresorptive effects of RANKL are prevented by binding to its soluble inhibitor osteoprotegerin (OPG). Recombinant human OPG-Fc recognizes RANKL from multiple species and reduced bone resorption and increased bone volume, density, and strength(More)
We and others recently reported tumor necrosis factor (TNF) and apoptosis ligand-related leukocyte-expressed ligand 1 (TALL-1) as a novel member of the TNF ligand family that is functionally involved in B cell proliferation. Transgenic mice overexpressing TALL-1 have severe B cell hyperplasia and lupus-like autoimmune disease. Here, we describe expression(More)
To realize the medicinal potential of peptide toxins, naturally occurring disulfide-rich peptides, as ion channel antagonists, more efficient pharmaceutical optimization technologies must be developed. Here, we show that the therapeutic properties of multiple cysteine toxin peptides can be rapidly and substantially improved by combining direct chemical(More)
Long-term follow up is necessary to understand the natural history of treated Parkinson's disease (PD). The Longitudinal and Biomarker Study in PD (LABS-PD) is an observational study designed to prospectively measure the evolution of motor and non-motor features of PD and sample promising biomarkers from early to late stage illness. LABS-PD is organized on(More)
Calcium entry into T cells following antigen stimulation is crucial for nuclear factor of activated T cells (NFAT)-mediated T cell activation. The movement of calcium is mediated by calcium release-activated calcium (CRAC) channels. There are two key components of this channel: Orai1 is the pore-forming subunit located in the plasma membrane, and stromal(More)
The objective of this study was to examine a remote method for maintaining long-term contact with Parkinson's disease (PD) patients participating in clinical studies. Long-term follow-up of PD patients is needed to fill critical information gaps on progression, biomarkers, and treatment. Prospective in-person assessment can be costly and may be impossible(More)
With the growth of the Internet and increased demand for Web Services has come a heightened need for scalable wide-area group communication systems. The need for trust in such systems and the vulnerability of such systems to attack provide motivation to develop protocols that are intrusion-tolerant and able to provide critical services even during an attack(More)
Chancellor Robert J. Kibbee President Milton G. Bassin President Roscoe C. Brown, Jr. President Saul B. Cohen President Flora Mancuso Edwards President Leon M. Goldstein President John W. Kneller President Leonard Lief President Gerald W. Lynch President Robert E. Marshak President Kur t R. Schmeller President Ursula Schwerin President Joel Segall President(More)
s from the ASENT 2007 Annual Meeting March 5–8, 2007 Poster Abstract #1: Passive and Active Functional Tasks Are the Main Reasons for Treatment of Upper Limb Spasticity in Post-Stroke Patients Among Neurologists, Physiatrists, and Primary Care Physicians Amanda M. VanDenburgh, Susan Abu-Shakra, Mitchell F. Brin, and Frederick Beddingfield III Allergan,(More)
  • 1