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OBJECTIVE To demonstrate subacute progression of brain atrophy (from 4.5-29mo postinjury) in moderate to severe traumatic brain injury (TBI) using structural magnetic resonance imaging (MRI). DESIGN Within-subjects, repeated-measures design. SETTING Inpatient neurorehabilitation program and teaching hospital (MRI department). PARTICIPANTS Adults(More)
BACKGROUND AND PURPOSE In stroke patients, obstructive sleep apnea (OSA) is associated with poorer functional outcomes than in those without OSA. We hypothesized that treatment of OSA by continuous positive airway pressure (CPAP) in stroke patients would enhance motor, functional, and neurocognitive recovery. METHODS This was a randomized, open label,(More)
BACKGROUND Chronic traumatic encephalopathy (CTE) is the term coined for the neurodegenerative disease often suspected in athletes with histories of repeated concussion and progressive dementia. Histologically, CTE is defined as a tauopathy with a distribution of tau-positive neurofibrillary tangles (NFTs) that is distinct from other tauopathies, and(More)
OBJECTIVE To demonstrate subacute progression of white matter (WM) injury (4.5mo-2.5y postinjury) in patients with traumatic brain injury using diffusion-tensor imaging. DESIGN Prospective, repeated-measures, within-subjects design. SETTING Inpatient neurorehabilitation program and teaching hospital MRI department. PARTICIPANTS Brain-injured adults(More)
OBJECTIVE To assess prospectively the degree of postrecovery long-term cognitive decline after moderate to severe traumatic brain injury (TBI). DESIGN Observational cohort. SETTING Inpatient rehabilitation hospital. PARTICIPANTS Adults (N=33) with moderate and severe TBI from a well characterized sample with low attrition. INTERVENTIONS Not(More)
OBJECTIVES To examine long-term outcome of moderate to severe traumatic brain injury (TBI) on timed and untimed cognitive tests using meta-analysis. DESIGN Meta-analysis examining outcome at 2 epochs, 6 to 18 months postinjury (epoch 1) and 4.5 to 11 years postinjury (epoch 2). SETTING Data source was published articles (1966-2007) identified through(More)
OBJECTIVES While a growing number of studies provide evidence of neural and cognitive decline in traumatic brain injury (TBI) survivors during the post-acute stages of injury, there is limited research as of yet on environmental factors that may influence this decline. The purposes of this paper, therefore, are to (1) examine evidence that environmental(More)
OBJECTIVE To ascertain patterns of cognitive recovery during the first year after traumatic brain injury (TBI). Specifically, differential recovery across cognitive domains was investigated. DESIGN Prospective, longitudinal, naturalistic, 1-year follow-up study. SETTING Large, urban inpatient neurorehabilitation program. PARTICIPANTS Patients (N=75)(More)
UNLABELLED We examined whether facial emotion perception was compromised in adults with recent traumatic brain injury (TBI). Few studies have examined emotion perception in TBI; those that have, examined chronic patients only. Recent and chronic TBI populations differ according to degree of functional reorganization of the brain, use of compensatory(More)
Estimation of premorbid IQ in traumatic brain injury (TBI) is clinically and scientifically valuable because it permits the quantification of the cognitive impact of injury. This is achieved by comparing performances on tests of current ability to estimates of premorbid IQ, thereby enabling current capacity to be interpreted in light of preinjury ability.(More)