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516 S udden cardiac death (SCD) remains a high priority public health problem necessitating a multi-pronged approach for treatment and prevention. Tachyarrhythmic sudden cardiac death (SCD-VT/VF; ie, death attributable to potentially reversible ventricular tachyarrhythmias [ventricular tachy-cardia (VT) or fibrillation (VF)]), is a major cause of SCD.(More)
IMPORTANCE Chelation therapy with disodium EDTA has been used for more than 50 years to treat atherosclerosis without proof of efficacy. OBJECTIVE To determine if an EDTA-based chelation regimen reduces cardiovascular events. DESIGN, SETTING, AND PARTICIPANTS Double-blind, placebo-controlled, 2 × 2 factorial randomized trial enrolling 1708 patients aged(More)
Plasmin-alpha2-antiplasmin complex (PAP) marks plasmin generation and fibrinolytic balance. We recently observed that elevated levels of PAP predict acute myocardial infarction in the elderly, yet little is known about the correlates of PAP. We measured PAP in 800 elderly subjects who were free of clinical cardiovascular disease in 2 cohort studies: the(More)
2532 S udden cardiac arrest (SCA) remains an important public health challenge. Despite a dramatic decrease in the age-adjusted risk of SCA, the cumulative number of fatal SCAs in the United States remains large. Estimates range from <170 000 to >450 000 fatal SCAs per year; a figure in the range of 300 000 to 370 000 per year is likely the best current(More)
to provide recommendations to the NHLBI that would guide informed decisions on research directions and priorities in the field of cardiovas-cular pharmacogenomics. This meeting was timed to follow the New Frontiers in Personalized Medicine: Cardiovascular Research and Clinical Care conference held the previous day and cosponsored by the NHLBI, Personalized(More)
1 F or >50 years, ethylene diamine tetraacetic acid (EDTA)-based chelation therapy has been used by practitioners to treat complications of atherosclerosis, without a robust evidence base, and with increasing controversy. 4 by the National Center for Complementary and Alternative Medicine and the National Heart, Lung, and Blood Institute, was designed as a(More)
2532 S udden cardiac arrest (SCA) remains an important public health challenge. Despite a dramatic decrease in the age-adjusted risk of SCA, the cumulative number of fatal SCAs in the United States remains large. Estimates range from <170 000 to >450 000 fatal SCAs per year; a figure in the range of 300 000 to 370 000 per year is likely the best current(More)
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