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Rheumatoid arthritis (RA) is characterized by synovial inflammation and hyperplasia. Fibroblast-like synoviocytes (FLSs) are apoptosis-resistant and contribute to the pathogenesis of RA by producing cytokines and proteolytic enzymes, which degrade the extracellular matrix. We evaluated the proapoptotic and anti-inflammatory activity of the small molecule… (More)
In the Italian Alps the intensification of winter sports represents an increasing threat for Black Grouse (Tetrao tetrix). During the winters 2010/2011 and 2011/2012, characterised by different amounts of snowfall, 58 droppings from as many snow burrows were collected in three areas with different human disturbance to evaluate its effects on Black Grouse… (More)
Helminths have often been considered responsible in driving partially wildlife population density fluctuations; therefore more information have to be achieved when target hosts are endangered or threatened species, such as black grouse (Tetrao tetrix). During 8 years (2003–2010), we collected and analyzed 431 intestinal contents of hunted black grouse from… (More)
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Purpose: Justify the capability to obtain feasible assembly sequences through an automatic approach based only on contact and interference information between components of a mechanical discrete product, independently of adopted virtual modelling techniques and human intervention. Analysis of assembly information available at early stages of design in… (More)
The complex life cycle of Toxoplasma gondii involves many animal species, raising zoonotic, economic, and conservation issues. This complexity is reflected in the molecular structure of T. gondii, whose different genotypes differ in pathogenicity. Among the intermediate hosts of T. gondii, wild ungulates may be a source of human infection. Despite intense… (More)
Knowledge plays a fundamental role inside the industrial reality, being closely connected to the efficiency of the entire lifecycle of a product. In this work the authors present the use of the Concept Map as a form of simplifying, storing and communicating the technical concepts that stand behind a normative. The normative of reference is the one related… (More)