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BACKGROUND AND OBJECTIVES The pro-inflammatory cytokine interleukin (IL)-1 has been suggested to play a role in atherosclerosis. Several genetic polymorphisms have been described in the genes of the IL-1 cluster and associations with coronary artery disease (CAD) have been reported, although with contrasting results. DESIGN AND METHODS The associations of(More)
We perform a comprehensive exploration of the Constrained MSSM parameter space employing a Markov Chain Monte Carlo technique and a Bayesian analysis. We compute superpart-ner masses and other collider observables, as well as a cold dark matter abundance, and compare them with experimental data. We include uncertainties arising from theoretical(More)
We use a newly released version of the SuperBayeS code to analyze the impact of the choice of priors and the influence of various constraints on the statistical conclusions for the preferred values of the parameters of the Constrained MSSM. We assess the effect in a Bayesian framework and compare it with an alternative likelihood-based measure of a profile(More)
With the recent rapid increase in scientific understanding of the human genome it is becoming possible to identify the extent to which genetic variations influence drug response. The emergence of pharmacogenetics heralds a new era in which drug therapies will be selected on the basis of differences in individuals' genotypes, enhancing drug safety and(More)
We study the properties of the constrained minimal supersymmetric standard model (mSUGRA) by performing fits to updated indirect data, including the relic density of dark matter inferred from WMAP5. In order to find the extent to which µ < 0 is disfavoured compared to µ > 0, we compare the Bayesian evidence values for these models, which we obtain(More)
We reexamine the properties of the Constrained MSSM in light of updated constraints , paying particular attention to the impact of the recent substantial shift in the Standard Model prediction for BR(B → X s γ). With the help of a Markov Chain Monte Carlo scanning technique, we vary all relevant parameters simultaneously and derive Bayesian posterior(More)
We examine the prospects of detecting the light Higgs scalar h 0 of the Constrained MSSM at the Tevatron. To this end we explore large ranges of the CMSSM parameter space with µ > 0 using a Markov Chain Monte Carlo technique, and apply all relevant collider and cosmological constraints including their uncertainties, as well as those of the Standard Model(More)
We consider an analytic model of cosmic star formation which incorporates supernova feedback, gas accretion and enriched outflows, reproducing the history of cosmic star formation, metallicity, supernovae type II rates and the fraction of baryons allocated to structures. We present a new statistical treatment of the available observational data on the star(More)