Roberto Tommasini

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OBJECTIVE The aim of the present study was to investigate gene expression during the in vitro redifferentiation process of human articular chondrocytes isolated from clinical samples from patient undergoing an autologous chondrocyte transplantation therapy (ACT). METHOD Monolayer (ML) expanded human articular chondrocytes from four donors were cultured in(More)
The expansion of chondrocytes in automated bioreactors for clinical use requires that a relevant number of cells be generated, starting from variable initial seeding densities in one passage and using autologous serum. We investigated whether the growth factor combination transforming growth factor beta 1/fibroblast growth factor 2/platelet-derived growth(More)
Roberto Tommasini, Enrico Martinoia, Erwin Grill, Karl-Josef Dietz*, and Nikolaus Amrhein Institut für Pflanzenwissenschaften, ETH Zürich, Sonneggstraße 5, CH-8092 Zürich, Switzerland * Julius-von-Sachs-Institut für Biowissenschaften, Mittlerer Dallenbergweg 64, D-97082 Würzburg, Bundesrepublik Deutschland Z. Naturforsch. 48c, 867-871 (1993); received(More)
Indoprofen is an isoindoline derivative of phenylpropionic acid. At doses of 1-3 mg/kg it inhibited acute and subchronic experimental inflammation. Its strong analgesic activity lacks any specific CNS effect. The drug's pharmacological activity is directly related to inhibition of prostaglandin biosynthesis at the cyclo-oxygenase step. In(More)
Glipizide, a new sulfonylurea recently introduced for the treatment of diabetes, was studied to check its possible extrapancreatic effects. Rats were given a subcutaneous injection of 1 g/kg glucosamine: this dose caused marked hyperglycemia and a decrease in hepatic glycogen, but does not alter blood insulin levels. Pretreatment with i.v. dose of 37.5(More)