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Expression of TMEM16A protein is associated with the activity of Ca(2+)-activated Cl(-) channels. TMEM16A primary transcript undergoes alternative splicing. thus resulting in the generation of multiple isoforms. We have determined the pattern of splicing and assessed the functional properties of the corresponding TMEM16A variants. We found three alternative(More)
TMEM16A protein, also known as anoctamin-1, has been recently identified as an essential component of Ca(2+)-activated Cl(-) channels. We previously reported the existence of different TMEM16A isoforms generated by alternative splicing. In the present study, we have determined the functional properties of a minimal TMEM16A protein. This isoform, called(More)
The ASSIST environment provides a high-level programming toolkit for the grid. ASSIST applications are described by means of a coordination language, which can express arbitrary graphs of modules. These modules (or a graph of them) may be enclosed in components specifically designed for the grid (GRID.it components). In this paper we describe how ASSIST(More)
We describe the implementation of ASSIST, a programming environment for parallel and distributed programs. Its coordination language is based of the parallel skeleton model, extended with new features to enhance expressiveness, parallel software reuse, software component integration and interfacing to external resources. The compilation process and the(More)
  • Francesca Giacopelli, Renato Marciano, Angela Pistorio, Paolo Catarsi, Silvana Canini, Gerard Karsenty +1 other
  • 2004
Understanding the molecular mechanisms that underlie regulation of transcription of the human osteopontin encoding gene (OPN) may help to clarify several processes, such as fibrotic evolution of organ damage, tumorigenesis and metastasis, and immune response, in which OPN overexpression is observed. With the aim to evaluate variants with functional effect(More)
We describe how the ASSIST parallel programming environment can be used to run parallel programs on collections of heterogeneous workstations and evaluate the scalability of one task-farm real application and a data-parallel benchmark, comparing the actual performance figures measured when using homogeneous and heterogeneous workstation clusters. We(More)
ASSIST is a parallel programming environment aimed at providing programmers of complex parallel application with a suitable and effective programming tool. Being based on algoritmical skeletons and coordination languages technologies, the programming environment relieves the programmer from a number of cumbersome, error prone activities that are required(More)
The effects of mGlu1 and mGlu5 receptor activation on the depolarization-evoked release of [3H]d-aspartate ([3H]D-ASP) from mouse cortical synaptosomes were investigated. The mGlu1/5 receptor agonist 3,5-DHPG (0.1-100microM) potentiated the K+(12mM)-evoked [3H]D-ASP overflow. The potentiation occurred in a concentration-dependent manner showing a biphasic(More)