Roberto Dischinger Miranda

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Dystrophin is a cytoskeletal membrane-bound protein expressed in both muscle and brain. Brain dystrophin is thought to be involved in the stabilization of gamma-aminobutyric acid (GABA)(A)-receptor (GABA(A)-R)clusters in postsynaptic densities (PSDs) at inhibitory synapses onto pyramidal cells, and its loss has been linked to cognitive impairments in(More)
Cyclin-dependent kinase 5 (CDK5) is a cytoplasmic serine/ threonine kinase. Knockdown of CDK5 enhances paclitaxel sensitivity in human ovarian cancer cells. This study explores the mechanisms by which CDK5 regulates paclitaxel sensitivity in human ovarian cancers. Multiple ovarian cancer cell lines and xenografts were treated with CDK5 small interfering RNA(More)
Arterial hypertension (AH) is a highly prevalent disease, and is a major cardiovascular (CV) risk factor 1 ; therefore, achieving blood pressure (BP) control goals as soon as possible is paramount to reduce that risk 2. That means that approximately 70% of hypertensive individuals will need antihypertensive drug combination 3 , and up to 30% of hypertensive(More)
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