Roberto Di Maio

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DJ-1 deficiency is a cause of genetic Parkinson’s disease (PARK7 PD). In sporadic Parkinson’s disease (PD), however, DJ-1 is abundantly expressed in reactive astrocytes. This may represent a compensatory protective response. In initial support of this hypothesis, we have shown in vitro that DJ-1-overexpressing astrocytes protect neurons against(More)
The activity of voltage-gated K+ channels (Kv) can be dynamically modulated by several events, including neurotransmitter stimulated biochemical cascades mediated by G protein-coupled receptors such as 5-HT2 receptors (5-HT2Rs). Activation of 5-HT2A/CR inhibits the Shaker-like K+ channels Kv1.1 and Kv1.2, and this modulation involves the dual coordination(More)
Demonstrating the safety of modern Railway Control Systems based on microprocessors is more complicated than showing that of traditional relay systems, because the behaviour of microprocessors when faults occur is unpredictable. This paper presents an overview of the main Verification and Validation (V&V) methods used by the Reliability, Availability,(More)
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