Roberto Alegre

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Dengue virus infection has emerged as one of the most important arthropod-borne diseases. In some dengue-infected individual, the disease progresses to its severe, life-threatening form, dengue hemorrhagic fever (DHF). Host genetic factors may be relevant and predispose some individuals to the severe dengue disease. The unique history of dengue outbreaks in(More)
An HLA-E polymorphism study by oligotyping and DNA sequencing was carried out in the Spanish population. As a result, a new HLA-E allele (E*01031) initially assigned by polymerase chain reaction oligotyping as E*0104 was found. This allele presents a synonymous change at codon 77 (AAT-->AAC; Asn) when compared with the E*01032 allele. This position is(More)
The HLA-B locus is the most polymorphic of the class I genes encoded within the human major histocompatibility complex. This polymorphism is mainly located in exons 2 and 3, which code for the molecule's alpha1 and alpha2 domains and includes the antigenic peptide binding site. However, information about adjacent non-coding regions (introns 1 and 2) has not(More)
HLA-B is the most polymorphic class I locus (Parham et al. 1995). Recent evidence from isolated tribes of native South Americans, chimpanzees, and bonobos suggest that the HLA-B locus may be evolving more rapidly than HLA-A and HLA-C loci, possibly due to a particularly high recombination level together with point mutation events in exon 2 and exon 3(More)
Ten new primate Mhc-DMB complete cDNA sequences have been obtained in chimpanzee (n=four), gorilla (n=three) and orangutan (n=three); this gene has not been previously studied in these species. Exonic allelism has been recorded all along the molecule domains and also in the leader peptide, but not in the transmembrane segment. An analysis of the residues(More)
HLA-B40 is one of the most frequent HLA-B serologically defined antigens in the Mestizo and Indian Mexican populations (Weckmann et al. 1996, and unpublished data). In the present study, a new HLA-B40 subtype (B*4011) is described in a healthy 55-yearold man born in Mexico City; he comes from Puebla County, where the Nahua ethnic group is predominant. Nahua(More)
HLA-A2 and A28 are two of the most frequent HLA-A serologically defined antigens in the Mestizo and Indian Mexican populations (Weckmann et al. 1997, and unpublished data). In the present study, two new HLA-A*68 subtypes present in two unrelated individuals from the Mazatecan ethnic group were characterized and seen to belong to the A2/A28 family of(More)
Caribbean Islands including Cuba were first inhabited by Meso-American and later by Arawak-speaking Amerindians from nowadays Venezuela. Spanish invaders brought to almost extinction to the Amerindian population after 1492. Black slaves from West Africa were taken into Cuba by Europeans. The degree of admixture among populations is approached. HLA alleles(More)
Sequencing studies of HLA class II molecules have focused almost exclusively on exon 2. In this study the complete cDNA sequence of the DRB1*09012 allele is reported for the first time. This sequence was previously only partially published. In the DR9 antigen, two synonymous allelic variants (DRB1*09011 and 09012) were officially recognized, though it was(More)
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