Robert Wyatt

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Several semantic based user profile approaches have been introduced in the literature to learn the users' interests for per-sonalized search. However, many of them are ill-suited to cope with a domain of information that evolves and user interests that may change over time. In this paper, we propose a novel dual representation of a user's semantic profile(More)
This paper introduces a multi-model ontology-based framework for semantic search of educational content in E-learning repository of courses, lectures, multimedia resources, etc. This hybrid recommender system is driven by two types of recommendations: content-based (domain ontology model) and rule-based (learner’s interest-based and cluster-based).(More)
We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry. We identified six new genome-wide significant associations, four in ITGAM-ITGAX, VAV3 and CARD9 and two new independent signals at HLA-DQB1 and(More)
IgA nephropathy (IgAN), major cause of kidney failure worldwide, is common in Asians, moderately prevalent in Europeans, and rare in Africans. It is not known if these differences represent variation in genes, environment, or ascertainment. In a recent GWAS, we localized five IgAN susceptibility loci on Chr.6p21 (HLA-DQB1/DRB1, PSMB9/TAP1, and DPA1/DPB2(More)
The severity of renal involvement is the major factor determining the long-term outcome of children with Henoch-Schönlein purpura (HSP) nephritis (HSPN). Approximately 40% children with HSP develop nephritis, usually within 4 to 6 weeks after the initial onset of the typical purpuric rashes. Although the pathogenetic mechanisms are still not fully(More)
The Semantic Web has been evolved as a key technology, bringing new insights and solutions to well documented problems in E-learning. The research field of Semantic E-learning covers a wide range of research problems. In this paper, we present an approach to visualize an ontology driven information retrieval system in the context of E-learning. This(More)
BACKGROUND Circulating immune complexes (CIC) containing galactose (Gal)-deficient IgA1 from adults with IgA nephropathy (IgAN) induce proliferation of cultured mesangial cells, but activities of CIC from pediatric patients with the disease have not been studied. METHODS CIC of different sizes were isolated from sera of pediatric and adult IgAN patients(More)
IgA nephropathy (IgAN), the most common primary glomerulonephritis, is characterized by renal immunodeposits containing IgA1 with galactose-deficient O-glycans (Gd-IgA1). These immunodeposits originate from circulating immune complexes consisting of anti-glycan antibodies bound to Gd-IgA1. As clinical disease onset and activity of IgAN often coincide with(More)
Immunoglobulin A nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide and an important cause of kidney disease in young adults. Highly variable clinical presentation and outcome of IgAN suggest that this diagnosis may encompass multiple subsets of disease that are not distinguishable by currently available clinical tools.(More)