The efficacy of transcervical insertions of quinacrine hydrochloride pellets to produce tubal occlusion has been evaluated in a study of 139 women in Santiago, Chile. At one year, the pregnancy rate was 3.1%, an acceptable rate for a nonsurgical method of female sterilization.
The efficacy and tolerability of 80 mg propranolol tablets as a vaginal contraceptive were studied in 198 fertile women for 11 months. The calculated one year life table pregnancy rate was 3.4/100 women and the Pearl index was 3.9/100 women years. No major adverse effects were encountered. The findings suggested that propranolol is an effective vaginal… (More)
Extensive research has been undertaken to develop a simple method of non-surgical female sterilization. Zipper and associates identified quinacrine hydrochloride as a drug likely to produce tubal occlusion when placed into the uterus. Zipper's early work with a solution of quinacrine led to the development of quinacrine pellets, a delivery system that was… (More)
Abal~ct We have studied electron heating in a 2DEG in GaAs/AIGaAs heterojunctions below 0.5 IC The electron temperature was raised above the lattice temperature using Joule heat/n& Weak localiT~tion and the temperature-dependent sample resistance were used as thermometers for the electrons. The electron-phonon energy relaxation rate was found to be… (More)
The use of quinacrine hydrochloride as an effective chemical agent for trans-cervical female sterilization has been established primarily through the pioneering work of Jaime Zipper. 8*10*11*12 Current research is concerned with making the method commercially available through the development of dosage forms that will enhance the acceptance of the method… (More)
It is 15 years since Corfman reviewed transcervical oviduct occlusion and chronicled the history of the concept. * In 1849 a technique was developed to produce tubal occlusion with the application of silver nitrate to the cornua. Many other agents have since been evaluated for their tubal occlusive capabilities , such as zinc, phenol, chloride, sodium… (More)