Robert W. Hobson

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BACKGROUND AND PURPOSE Indications for carotid endarterectomy have engendered considerable debate among experts and have resulted in publication of retrospective reviews, natural history studies, audits of community practice, position papers, expert opinion statements, and finally prospective randomized trials. The American Heart Association assembled a(More)
BACKGROUND A heightened risk of stroke and death among octogenarians undergoing carotid artery stenting (CAS) has been reported. The multicenter Carotid Revascularization Endarterectomy vs. Stent Trial (CREST) supported by the National Institute of Neurological Disorders, National Institutes of Health, compares the efficacy of carotid endarterectomy (CEA)(More)
Hypertension Hypertension is the most powerful, prevalent, and treatable risk factor for stroke. Both systolic and diastolic blood pressure are independently related to stroke incidence. Isolated systolic hypertension, which is common in the elderly, also considerably increases risk of stroke. Reduction of elevated blood pressure significantly lowers risk(More)
BACKGROUND In the Carotid Revascularization Endarterectomy versus Stenting Trial, we found no significant difference between the stenting group and the endarterectomy group with respect to the primary composite end point of stroke, myocardial infarction, or death during the periprocedural period or any subsequent ipsilateral stroke during 4 years of(More)
PURPOSE We performed a randomized, double-blind, placebo-controlled, multicenter trial to evaluate the relative efficacy and safety of cilostazol and pentoxifylline. PATIENTS AND METHODS We enrolled patients with moderate-to-severe claudication from 54 outpatient vascular clinics, including sites at Air Force, Veterans Affairs, tertiary care, and(More)
Richard E. Latchaw, MD, Chair; Mark J. Alberts, MD, FAHA; Michael H. Lev, MD, FAHA; John J. Connors, MD; Robert E. Harbaugh, MD, FAHA; Randall T. Higashida, MD, FAHA; Robert Hobson, MD, FAHA†; Chelsea S. Kidwell, MD, FAHA; Walter J. Koroshetz, MD; Vincent Mathews, MD; Pablo Villablanca, MD; Steven Warach, MD, PhD; Beverly Walters, MD; on behalf of the(More)
PURPOSE The North American Subfascial Endoscopic Perforator Surgery (NASEPS) Registry was established to evaluate the safety, feasibility, and efficacy of minimally invasive endoscopic Linton operations for treatment of chronic venous insufficiency. METHODS Retrospective analysis was performed on the clinical data of 151 patients who underwent attempt at(More)
BACKGROUND The efficacy of carotid endarterectomy in patients with asymptomatic carotid stenosis has not been confirmed in randomized clinical trials, despite the widespread use of operative intervention in such patients. METHODS We conducted a multicenter clinical trial at 11 Veterans Affairs medical centers to determine the effect of carotid(More)
We tested the hypothesis that VEGF regulates endothelial hyperpermeability to macromolecules by activating the ERK-1/2 MAPK pathway. We also tested whether PKC and nitric oxide (NO) mediate VEGF-induced increases in permeability via the ERK-1/2 pathway. FITC-Dextran 70 flux across human umbilical vein endothelial cell monolayers served as an index of(More)
BACKGROUND The correlation of B-mode ultrasonographic morphology with histologic characteristics of atherosclerotic carotid plaques remains ill-defined. The classification of plaques with recently reported measures of plaque echogenicity and heterogeneity has been unsatisfactory. We used computer-assisted duplex ultrasound (DU) scan image analysis to(More)