Robert W. H. Fisher

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Smallpox, caused by variola virus (VARV), is a devastating human disease that affected millions worldwide until the virus was eradicated in the 1970 s. Subsequent cessation of vaccination has resulted in an immunologically naive human population that would be at risk should VARV be used as an agent of bioterrorism. The development of antivirals and improved(More)
A33 is a type II integral membrane protein expressed on the extracellular enveloped form of vaccinia virus (VACV). Passive transfer of A33-directed monoclonal antibodies or vaccination with an A33 subunit vaccine confers protection against lethal poxvirus challenge in animal models. Homologs of A33 are highly conserved among members of the Orthopoxvirus(More)
The pharmacological characteristics of a pre-junctional 5-HT autoreceptor have been studied by following the Ca2+-dependent, K+-evoked release of [3H]-5-HT from preloaded rat frontal cortex slices. Added 5-HT, in the presence of the 5-HT uptake inhibitor chlorimipramine, caused a dose related inhibition of the K+-evoked release of [3H]-5-HT in this system(More)
BACKGROUND Previously we demonstrated that DNA vaccination of nonhuman primates (NHP) with a small subset of vaccinia virus (VACV) immunogens (L1, A27, A33, B5) protects against lethal monkeypox virus challenge. The L1 and A27 components of this vaccine target the mature virion (MV) whereas A33 and B5 target the enveloped virion (EV). RESULTS Here, we(More)
BACKGROUND Influenza infection causes excess hospitalizations and deaths in younger patients, but susceptibility to severe disease is poorly understood. While mucosal antibodies can limit influenza-associated infection and disease, little is known about acute mucosal antibody responses to influenza infection. OBJECTIVES These studies characterize mucosal(More)
RATIONALE Humans with a dominant negative mutation in STAT3 are susceptible to severe skin infections, suggesting an essential role for STAT3 signaling in defense against cutaneous pathogens. METHODS To focus on innate antiviral defenses in keratinocytes, we used a standard model of cutaneous infection of severe combined immunodeficient mice with the(More)
Thanks to all my friends and family for their support, particularly my wife Katherine, without whom none of this would be possible. Abstract As the availability of unstructured data on the web continues to increase, it is becoming increasingly necessary to develop machine learning methods that rely less on human annotated training data. In this thesis, we(More)
of the trail following responses of four species of leap cutting ants with notes on the specificity of a trail pheromone of Atta tewna (Buckley). Insectes Sociaux 21: 87-94. capabilities of the "gustatory" chemo-receptors of the tobacco hornworm larvae. ABSTRACT Electsoantennograms (EAGs) were recorded from major workers, queens, and males of the Texas leaf(More)