Robert W Grundmeier

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OBJECTIVE Two recent genome-wide association (GWA) studies have revealed novel loci for type 1 diabetes, a common multifactorial disease with a strong genetic component. To fully utilize the GWA data that we had obtained by genotyping 563 type 1 diabetes probands and 1,146 control subjects, as well as 483 case subject-parent trios, using the Illumina(More)
Clinical research relies on enrollment of appropriate subjects. Individuals who hear about research from their clinician are more likely to participate. We developed two strategies for research subject enrollment using the EHR and its underlying data: pop-up alerts for clinicians, and patient lists for on-site research assistants. Eleven studies used(More)
OBJECTIVE Clinicians' ability to use and interpret genetic information depends upon how those data are displayed in electronic health records (EHRs). There is a critical need to develop systems to effectively display genetic information in EHRs and augment clinical decision support (CDS). MATERIALS AND METHODS The National Institutes of Health(More)
OBJECTIVE To improve human papillomavirus (HPV) vaccination rates, we studied the effectiveness of targeting automated decision support to families, clinicians, or both. METHODS Twenty-two primary care practices were cluster-randomized to receive a 3-part clinician-focused intervention (education, electronic health record-based alerts, and audit and(More)
OBJECTIVE To measure housestaff attitudes towards computer-based decision support and their threshold for having CDSS messages displayed. DESIGN 770 self-administered surveys were distributed to housestaff physicians. RESULTS 209 surveys were returned. 63% of respondents agreed or strongly agreed that CDSS would improve quality of care, while 52% agreed(More)
OBJECTIVE To determine whether racial differences exist in antibiotic prescribing among children treated by the same clinician. METHODS Retrospective cohort study of 1,296,517 encounters by 208,015 children to 222 clinicians in 25 practices in 2009. Clinical, antibiotic prescribing, and demographic data were obtained from a shared electronic health(More)
OBJECTIVE To assess the effects of electronic health record-based clinical decision support (CDS) and physician performance feedback on adherence to guidelines for acute otitis media (AOM) and otitis media with effusion (OME). METHODS We conducted a factorial-design cluster randomized trial with primary care practices (n = 24) as the unit of randomization(More)
We developed an electronic medical record (EMR)-based HPV vaccine decision support intervention targeting clinicians, (immunization alerts, education, and feedback) and families (phone reminders and referral to an educational website). Through telephone surveys completed by 162 parents of adolescent girls, we assessed the acceptability of the family-focused(More)
OBJECTIVE To evaluate the architecture, integration requirements, and execution characteristics of a remote clinical decision support (CDS) service used in a multicenter clinical trial. The trial tested the efficacy of implementing brain injury prediction rules for children with minor blunt head trauma. MATERIALS AND METHODS We integrated the Epic(®)(More)
IMPORTANCE Early-life antibiotic exposure has been associated with increased adiposity in animal models, mediated through the gut microbiome. Infant antibiotic exposure is common and often inappropriate. Studies of the association between infant antibiotics and childhood weight gain have reported inconsistent results. OBJECTIVE To assess the association(More)