Robert W. Cook

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Activins are members of the transforming growth factor (TGF) beta (beta) superfamily of proteins that function in a wide array of physiological processes. Like other TGFbeta ligands, activins are biologically active as dimers. An activin molecule is comprised of two beta-subunits, of which four isoforms have been identified: betaA, betaB, betaC, and betaE.(More)
There is strong evidence that patients with AIDS have loss of cortical neurons. In this study we have examined the hippocampus of rhesus monkeys infected with simian immunodeficiency virus (SIV) to determine whether neuronal damage occurs in this model of human AIDS and to investigate its time course. Twenty-eight infected monkeys (23 young [< 9 years] and(More)
Platelet-derived growth factor alpha (PDGFA) is frequently upregulated in various cancers and thought to function as a key player in the development and progression of tumor growth by regulating aspects of cell proliferation, angiogenesis and metastasis. However, the mechanism by which it is upregulated is not fully understood. Previously, we demonstrated(More)
OBJECTIVE Assess current clinical practices for uveal melanoma (UM) and the impact of molecular prognostic testing on treatment decisions. DESIGN Cross-sectional survey and sequential medical records review. PARTICIPANTS Ophthalmologists who treat UM. METHODS (A) Medical records review of all Medicare beneficiaries tested by UM gene expression profile(More)
PURPOSE Thymoma represents one of the rarest of all malignancies. Stage and completeness of resection have been used to ascertain postoperative therapeutic strategies albeit with limited prognostic accuracy. A molecular classifier would be useful to improve the assessment of metastatic behaviour and optimize patient management. METHODS qRT-PCR assay for(More)
pCDNA3 or betaglycan-c-myc (BG-c-myc). A) Cells were treated with 100 ng/ml human activin A or empty vector culture media (EV media). The cell lysate was immunoprecipitated by monoclonal anti-HA or mouse IgG, followed by immunoblot with anti-β A-subunit polyclonal antibody. B) Cells were treated with 100 ng/ml human activin A (panel 1); empty vector (panel(More)
Uveal melanoma management is challenging due to its metastatic propensity. DecisionDx-UM is a prospectively validated molecular test that interrogates primary tumor biology to provide objective information about metastatic potential that can be used in determining appropriate patient care. To evaluate the continued clinical validity and utility of(More)
Transforming growth factor-beta (TGFbeta) homologues form a diverse superfamily that arose early in animal evolution and control cellular function through membrane-spanning, conserved serine-threonine kinases (RII and RI receptors). Activin and inhibin are related dimers within the TGFbeta superfamily that share a common beta-subunit. The evolution of the(More)
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