Robert Vander Broek

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Head and neck squamous cell carcinoma (HNSCC) arises from the upper aerodigestive tract and is the six most common cancers worldwide. HNSCC is associated with high morbidity and mortality, as standard surgery, radiation, and chemotherapy can cause significant disfigurement and only provide 5-year survival rates of ~50-60%. The heterogeneity of HNSCC subsets(More)
Purpose: Invasion is the critical step in progression of a precancerous lesion to squamous cell carcinoma of the head and neck (HNSCC). Invasion is regulated by multiple proinflammatory mediators. Tristetraprolin (TTP) is anmRNA-degrading protein that regulatesmultiple proinflammatorymediators. TTPmay serve as an excellent treatment target. Rap1 is a(More)
Purpose: Head and neck squamous cell carcinomas exhibit variable sensitivity to inhibitors of the PI3K/mTOR pathway, an important target of genomic alterations in this cancer type. The mitogen-activated protein kinase kinase (MEK)/ERK/activator protein 1 (AP-1) and nuclear factor-kB (NF-kB) pathways are also frequently co-activated, but their roles in(More)
Purpose: PI3K-mTOR pathway activation is often associated with altered expression or mutations of PIK3CA, TP53/p73, PTEN and TGFβR in head and neck squamous cell carcinomas (HNSCC). However, little is known about how these alterations affect response to PI3K-mTOR targeted agents. Experimental Design: In this preclinical study, PI3K-Akt-mTOR signaling was(More)
Squamous cell carcinoma of the head and neck (SCCHN) is an aggressive diseasewith poor patient survival. Galanin receptor 2 (GALR2) is a G protein–coupled receptor that induces aggressive tumor growth in SCCHN. The objective of this studywas to investigate themechanismbywhichGALR2promotes angiogenesis, a critical oncogenic phenotype required for tumor(More)
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