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Triglyceride accumulation protects against fatty acid-induced lipotoxicity
This work demonstrates in cultured cells that the relative toxicity of two common dietary long chain fatty acids is related to channeling of these lipids to distinct cellular metabolic fates, and supports a model of cellular lipid metabolism in which unsaturated fatty acids serve a protective function against lipotoxicity though promotion of triglyceride accumulation. Expand
A dual thrombin receptor system for platelet activation
It is reported that thrombin responses in platelets from PAR3-deficient mice were markedly delayed and diminished but not absent, and the identification of a two-receptor system for platelet activation byThrombin has important implications for the development of antithrombotic therapies. Expand
Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation
It is demonstrated that SIRT3 has evolved to control reversible lysine acetylation in this organelle and is shown to be a soluble mitochondrial protein. Expand
Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis.
An expressed sequence tag clone that shared regions of similarity with acyl CoA:cholesterol acyltransferase, an enzyme that also uses fatty acyl coA as a substrate was identified, which will greatly facilitate studies of cellular glycerolipid metabolism and its regulation. Expand
Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor
It is reported that the ketone body d-β-hydroxybutyrate (βOHB) is an endogenous and specific inhibitor of class I histone deacetylases (HDACs), and treatment of mice with βOHB conferred substantial protection against oxidative stress. Expand
SIRT 3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
Sirtuins are NAD-dependent protein deacetylases. They mediate adaptive responses to a variety of stresses, including calorie restriction and metabolic stress. Sirtuin 3 (SIRT3) is localized in theExpand
Functional genomic screen reveals genes involved in lipid-droplet formation and utilization
It is shown by means of a genome-wide RNA interference screen in Drosophila S2 cells that about 1.5% of all genes function in lipid-droplet formation and regulation, and a subset of the Arf1–COPI vesicular transport proteins also regulated droplet morphology and lipid utilization, thereby identifying a previously unrecognized function for this machinery. Expand
Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.
It is concluded that CCR2-/- mice have significant defects in both delayed-type hypersensitivity responses and production of Th1-type cytokines, suggesting an important and unexpected role for C CR2 activation in modulating the immune response, as well as in recruiting monocytes/macrophages to sites of inflammation. Expand
Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat
It is shown that Dgat-deficient (Dgat−/−) mice are viable and can still synthesize triglycerides, and these mice are lean and resistant to diet-induced obesity. Expand
Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets.
The results explain how TG synthesis is coupled with LD growth and identify two distinct LD subpopulations based on their capacity for localized TG synthesis. Expand