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In vertebrates, homologous recombinational repair (HRR) requires RAD51 and five RAD51 paralogs (XRCC2, XRCC3, RAD51B, RAD51C and RAD51D) that all contain conserved Walker A and B ATPase motifs. In human RAD51D we examined the requirement for these motifs in interactions with XRCC2 and RAD51C, and for survival of cells in response to DNA interstrand… (More)
We propose a new constructive algorithm for learning binary-to-binary mappings. Weight constraints derived from a spectral summation are used to check separability during the partitioning phase, and to limit hyperplane movement during training.
Homologous recombinational repair (HRR) restores chromatid breaks arising during DNA replication and prevents chromosomal rearrangements that can occur from the misrepair of such breaks. In vertebrates, five Rad51 paralogs are identified that contribute in a nonessential but critical manner to HRR proficiency. We constructed and characterized a knockout of… (More)
Escherichia coli strains are classified based on O-antigens that are components of the lipopolysaccharide (LPS) in the cell envelope. O-antigens are important virulence factors, targets of both the innate and adaptive immune system, and play a role in host-pathogen interactions. Because they are highly immunogenic and display antigenic specificity unique… (More)
The legend for S1 Fig is missing. Please view a corrected version of S1 Fig below. OX-groups are diagrammatically represented. The nucleotide sequences of 71 O-groups marked with asterisk and in bold font were determined in the present investigation. Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed,… (More)