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  • Gregory J. Brunn, Josie M Williams, Candace J. Sabers, Gregory J. Wiederrecht, John C. Lawrence, Robert T. Abraham
  • Biology, Medicine
  • The EMBO journal
  • 1996 (First Publication: 1 October 1996)
  • The immunosuppressant, rapamycin, inhibits cell growth by interfering with the function of a novel kinase, termed mammalian target of rapamycin (mTOR). The putative catalytic domain of mTOR isContinue Reading
  • Jann N Sarkaria, Randal S. Tibbetts, Ericka C. Busby, A P Kennedy, David E. Hill, Robert T. Abraham
  • Biology, Medicine
  • Cancer research
  • 1998 (First Publication: 1 October 1998)
  • Members of the phosphatidylinositol-3 kinase related kinase (PIKK) family function in both cell cycle progression and DNA damage-induced cell cycle checkpoints. The fungal metabolite, wortmannin, isContinue Reading
  • Aleksandar D Sekulic, Christine C. Hudson, +4 authors Robert T. Abraham
  • Biology, Medicine
  • Cancer research
  • 2000 (First Publication: 1 July 2000)
  • The microbially derived antiproliferative agent rapamycin inhibits cell growth by interfering with the signaling functions of the mammalian target of rapamycin (mTOR). In this study, we demonstrateContinue Reading