Robert Sharp

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Serine integrases catalyze the integration of bacteriophage DNA into a host genome by site-specific recombination between 'attachment sites' in the phage (attP) and the host (attB). The reaction is highly directional; the reverse excision reaction between the product attL and attR sites does not occur in the absence of a phage-encoded factor, nor does(More)
Members of the tyrosine recombinase (YR) family of site-specific recombinases catalyze DNA rearrangements using phosphoryl transfer chemistry that is identical to that used by the type IB topoisomerases (TopIBs). To better understand the requirements for YR catalysis and the relationship between the YRs and the TopIBs, we have analyzed the in vivo and in(More)
We present new measurements of the luminosity function (LF) of luminous red galaxies (LRGs) from the Sloan Digital Sky Survey (SDSS) and the 2dF SDSS LRG and Quasar (2SLAQ) survey. We have carefully quantified, and corrected for, uncertainties in the K and evolutionary corrections, differences in the colour selection methods, and the effects of photometric(More)
The U.S. Army has a need for continuous, accurate estimates of the wet bulb globe temperature to protect soldiers and civilian workers from heat-related injuries, including those involved in the storage and destruction of aging chemical munitions at depots across the United States. At these depots, workers must don protective clothing that increases their(More)
(2007). The 2dF-SDSS LRG and QSO Survey: the LRG 2-point correlation function and redshift-space distortions. Copyright and Moral Rights for the articles on this site are retained by the individual authors and/or other copyright owners. For more information on Open Research Online's data policy on reuse of materials please consult the policies page.
The survival motor neuron (SMN) protein forms the oligomeric core of a multiprotein complex required for the assembly of spliceosomal small nuclear ribonucleoproteins. Deletions and mutations in the SMN1 gene are associated with spinal muscular atrophy (SMA), a devastating neurodegenerative disease that is the leading heritable cause of infant mortality.(More)
We present initial results of a new, systematic search for massive star-formation in the host galaxies of the most luminous and probably most massive z > ∼ 4 radio-quiet quasars (M B ≤ −27.5; νL ν (1450Å) > 10 13 L ⊙). The survey, undertaken at 850µm using SCUBA at the James Clerk Maxwell Telescope (JCMT), has a target sensitivity limit of 3σ ∼10mJy, set to(More)
The Galaxy And Mass Assembly (GAMA) survey has been operating since February 2008 on the 3.9-m Anglo-Australian Telescope using the AAOmega fibre-fed spec-trograph facility to acquire spectra with a resolution of R ≈ 1300 for 120 862 SDSS selected galaxies. The target catalogue constitutes three contiguous equatorial regions centred at 9 h (G09), 12 h (G12)(More)