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OBJECTIVE The goal of this study was to characterize the hippocampal formation in patients with schizophrenia by measuring neuron density, neuron size, and variability of neuronal axis orientation. METHOD Brain tissue was obtained at autopsy from 14 prospectively accrued elderly patients with chronic schizophrenia and 10 age-compatible individuals without(More)
  • Jeffrey R Lax, Justin H Phillips, Justin, H Phillips, We Thank, Bernd Beber +7 others
  • 2008
We compare two approaches for estimating state-level public opinion: disaggregation by state of national surveys and a simulation approach using multilevel modeling of individual opinion and poststratification by population share. We present the first systematic assessment of the predictive accuracy of each and give practical advice about when and how each(More)
  • Brian Burgoon, Jowei Chen, David Epstein, Robert Erikson, Judith Goldstein, Shi-Geo Hirano +12 others
  • 2011
D oes globalization's impact on the labor market affect how people vote? I address this question using a new dataset based on plant-level data that measures the impact of foreign competition on the U.S. workforce over an 8-year period. Analyzing change in the president's vote share, I find that voters were substantially more sensitive to the loss of local(More)
For decades, the Democrats have been viewed as the party of the poor, with the Republicans representing the rich. Recent presidential elections, however, have shown a reverse pattern, with Democrats performing well in the richer blue states in the northeast and coasts, and Republicans dominating in the red states in the middle of the country and the south.(More)
BACKGROUND The pharmacological properties and distribution of a recently cloned member of the dopamine D2 receptor subfamily, the D3 receptor, has led directly to the hypothesis that it may be the target of antipsychotic action. METHODS To quantify D3 receptors, we characterized the conditions for selective binding of the radioligand iodine 125-labeled(More)
OBJECTIVE The purpose of this study was to characterize the neuropsychiatric profile of elderly patients with schizophrenia and establish a patient registry for prospective ante-mortem and post-mortem studies. METHOD Medical records of all chronically institutionalized patients in eight state hospitals who were over the age of 65 and had a chart diagnosis(More)
PURPOSE To evaluate the MR findings in the central nervous systems of patients with deletions of the long arm of chromosome 18 (18q- syndrome). METHODS Sixteen patients with 18q- syndrome ranging in age from 3 to 46 years (mean, 17 years) were studied with high-field-strength MR imaging. Images were analyzed for abnormal T2 hyperintensity in the white(More)
Business Process Management Systems are a rich source of events that document the execution of processes and activities within these systems. Business Process Analytics is the family of methods and tools that can be applied to these event streams in order to support decision-making in organizations. The analysis of process events can focus on the behavior(More)
Our understanding of neuropsychiatric abnormalities in patients with deletions of the long arm of chromosome 18 (18q- syndrome) is based mainly on sporadic case reports. We characterized the neuropsychiatric phenotype in 27 patients across a wide age range (2-47 years) with breakpoints ranging from 18q22.3-18q21.2. Adaptive behavior scores (Vineland(More)
This paper presents a neurologic formulation for the clinical features of the schizophrenic syndrome, and tests it against a systematic, region by region review of available postmortem neuroanatomical and neuropharmacological data. Based on this review a model is proposed that postulates a developmental lesion affecting the midline neurotransmitter-specific(More)