Robert Schuon

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Der laryngopharyngeale Reflux (LPR) kann Ursache zahlreicher Erkrankungen sein, mit denen der HNO-Arzt täglich konfrontiert wird. Da sich der LPR vom gastroösophagealen Reflux (GÖR) unterscheidet, muss vor Therapiebeginn die Langzeit-pH-Messung direkt am Kehlkopf erfolgen. Dies ist durch ein neues Messsystem möglich. Mit dem pH-RESPONSE® wurde der pH-Wert(More)
BACKGROUND Laryngopharyngeal reflux disease (LPRD) can have various causes. Because LPRD differs from gastroesophageal reflux disease (GERD), the pH monitoring has to be performed directly next to the entrance of the larynx. This is now possible using a new system called pH-RESPONSE. METHODS The ambulatory pH was monitored using the double probe(More)
Angiogenic factors are discussed to participate in growth and promotion of juvenile nasopharyngeal angiofibroma (JNA). However, only few data are available and mechanisms remain unclear. In the presented study we analysed the expression and subcellular distribution of several angiogenic growth factors and receptors potentially involved in JNA-growth and(More)
PURPOSE To explore the presence of differentially expressed proteins in OSCC for discrimination of tumour and normal mucosa to establish potential biomarkers and therapeutic targets. EXPERIMENTAL DESIGN Paired protein samples of 12 individuals (tongue cancer and non-cancerous mucosa) were separated by two-dimensional polyacrylamid gel electrophoresis. The(More)
OBJECTIVE The cyclooxygenases (COX) 1 and 2 are the rate-limiting enzymes of prostaglandin E(2) (PGE(2)) synthesis, and the upregulation of COX-2 has been reported in tumors of different origins. The aim of our study was to quantify the PGE(2) expression in squamous cell carcinoma and surrounding mucosa, to analyze the potential of acetylsalicylic acid(More)
The dual role of the inducible NO synthase (iNOS) and NO signaling in head and neck squamous cell carcinoma (HNSCC) is a complex and can both promote or inhibit tumor progression. However, the underlying molecular mechanisms are not yet resolved in detail. We show for the first time that conditions, favoring low NO levels conferred resistance against(More)
Biomechanische Untersuchungen des Unterkiefers erweisen sich aufgrund seiner komplexen anatomischen Struktur als schwierig. Voraussetzung für eine korrekte rechnerische Rekonstruktion des biomechanischen Verhaltens sind die Herstellung eines geometrisch individuellen Modells sowie die Bestimmung der knochenspezifischen Materialparameter. Ziel unserer(More)
Hintergrund. Untersuchungen zum Vergleich verschiedener Osteosynthesekonzepte erfordern die Beachtung sowohl biomechanischer als auch biologischer Kriterien. Dabei sollten experimentelle Untersuchungen möglichst weit der In-vivo-Situation entsprechen. Ziel unserer Untersuchung war es, ein Frakturmodell zu entwickeln und mittels frakturierten und(More)
Biomechanical investigations of the mandible are difficult to perform due to a variety of conditions involved. For the appropriate reconstruction of biomechanical properties, a geometrically correct body model has to be established which fits to complex in vivo conditions. The aim of our study was to evaluate the use of finite-element models (FEM) for the(More)
Sonographic examination of the hypopharynx and the extrathoracic oesophagus can be difficult. Therefore, most surgeons prefer to utilise CT or MRI scanning. Surgery is planned on the basis of endoscopic findings combined with radiologic information. The aim of the present prospective study was to demonstrate that the combination of ultrasonography and(More)