Robert Schaefer

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Two patients with long-standing idiopathic chronic constipation, which responded only to large daily doses of laxatives and additional suppositories and enemas, were treated with the specific opioid antagonist, naloxone, on a single-blind crossover basis. Both patients responded to naloxone treatment, with increased passage of faeces and increased wet and(More)
AIMS To determine the prevalence of hepatitis A, B and C viruses in patients attending a methadone maintenance clinic in New York City. DESIGN Cross-sectional. SETTING The Adult Services Clinic of Weill Cornell Medical College, an urban hospital-affiliated methadone program. PARTICIPANTS Former heroin addicted adults (n = 103) on methadone maintenance(More)
Dynamic Reconfigurable Network-On-Chip Design provides a snapshot of the state-of-the art in research and development of dynamic reconfigurable network-on-chip designs. The papers' editors and authors are affiliated with institutions that span the The book is divided into five sections: the introduction, design methods, high-level programming, simulation(More)
What does it mean for a profession to be considered mature? How valid is the claim that software faults may be excused due to the immaturity of the field? In giving that claim serious consideration, one might assume that there are stages to maturity, that maturity doesn't arrive in the world fully formed. If so, an understanding of maturity may be found(More)
System of systems (SoS) is an emerging field in the design and development of complex systems that are built from large scale component systems. A SoS has the following attributes: operational and managerial independence of components, a geographic extent that limits control mechanisms to information exchange, an evolutionary nature, and emergent behavior.(More)
Myeloid-differentiated HL-60 cells were used to study the activation of G-proteins by receptor agonists. Following incubation of membranes with the photoreactive GTP analog. [alpha-32P]GTP azidoanilide, and subsequent exposure to ultraviolet light (254 nm), photolabeling of 40 kDa proteins comigrating with the Gi2 alpha-subunit was observed. Photolabeling(More)