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  • Robert S. Kerbel
  • Medicine
  • The New England journal of medicine
  • 2008
  • The current era of research in antiangiogenic therapy for cancer began in earnest in 1971 with the publication of Folkman's imaginative hypothesis,1 but 33 years would elapse before the first drugContinue Reading
  • John M. L. Ebos, Christina R. Lee, William Cruz-Muñoz, Georg A. Bjarnason, James G. Christensen, Robert S. Kerbel
  • Medicine, Biology
  • Cancer cell
  • 2009 (First Publication: 1 March 2009)
  • Herein we report that the VEGFR/PDGFR kinase inhibitor sunitinib/SU11248 can accelerate metastatic tumor growth and decrease overall survival in mice receiving short-term therapy in variousContinue Reading
  • Khalid Al-Nedawi, Brian M. Meehan, Robert S. Kerbel, Anthony C. Allison, Janusz Rak
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2009 (First Publication: 10 March 2009)
  • Activated EGF receptor (EGFR) plays an oncogenic role in several human malignancies. Although the intracellular effects of EGFR are well studied, its ability to induce and modulate tumor angiogenesisContinue Reading