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  • Abdul A. Waheed, Seppo Parkkila, +7 authors William S. Sly
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1997 (First Published: 11 November 1997)
  • Hereditary hemochromatosis (HH) is the most common autosomal recessive disorder known in humans. A candidate gene for HH called HFE has recently been cloned that encodes a novel member of the majorContinue Reading
  • Seppo Parkkila, Abdul A. Waheed, +5 authors William S. Sly
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1997 (First Published: 25 November 1997)
  • Hereditary hemochromatosis (HH) is a common autosomal recessive disease associated with loss of regulation of dietary iron absorption and excessive iron deposition in major organs of the body.Continue Reading
  • John K Olynyk, Timothy G. St. Pierre, Robert S. Britton, Elizabeth M. Brunt, Bruce R. Bacon
  • Medicine
  • The American Journal of Gastroenterology
  • 2005 (First Published: 1 April 2005)
  • OBJECTIVES:Hepatic fibrosis is a complication of hereditary hemochromatosis. The aim of this study was to determine whether the product of the magnitude and duration of hepatic iron exposure isContinue Reading
  • Robert E. Fleming, Mary C. Migas, +7 authors William S. Sly
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1999 (First Published: 16 March 1999)
  • Hereditary hemochromatosis (HH) is a common autosomal recessive disorder characterized by tissue iron deposition secondary to excessive dietary iron absorption. We recently reported that HFE, theContinue Reading
  • Robert S. Britton
  • Medicine
  • Seminars in liver disease
  • 1996
  • Figure 3 summarizes several proposed mechanisms of iron- or copper-induced hepatotoxicity. It has long been suspected that free radicals may play a role in iron- and copper-induced cell toxicityContinue Reading
  • Robert E. Fleming, Mary C. Migas, +5 authors William S. Sly
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2000 (First Published: 29 February 2000)
  • Hereditary hemochromatosis (HH) is a common autosomal recessive disorder characterized by excess absorption of dietary iron and progressive iron deposition in several tissues, particularly liver.Continue Reading