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OBJECTIVE The purpose of this study was to examine the association of exposures to tobacco smoke and environmental lead with attention deficit hyperactivity disorder (ADHD). METHODS Data were obtained from the National Health and Nutrition Examination Survey 1999-2002. Prenatal and postnatal tobacco exposure was based on parent report; lead exposure was(More)
BACKGROUND Prior studies have examined independent effects of a dopamine receptor D4 polymorphism (DRD4-7) and lead exposure on executive functions but not their interaction or the role of sex as a modifier of their effects. METHODS Multivariable analyses were used to examine effects of DRD4-7 genotype, 60-month blood lead level, and sex on spatial(More)
OBJECTIVE Because of significant individual variability in attention-deficit/hyperactivity disorder (ADHD) medication response, there is increasing interest in identifying genetic predictors of treatment effects. This study examined the role of four catecholamine-related candidate genes in moderating methylphenidate (MPH) dose-response. METHOD Eighty-nine(More)
CONTEXT Mental health disorders, substance use, and domestic violence often occur together. However, studies examining the impact of these conditions in mothers on the well-being of their children have focused only on isolated conditions. OBJECTIVE To examine the cumulative effect of maternal mental health disorders, substance use, and domestic violence(More)
BACKGROUND Bisphenol A (BPA), an endocrine-disrupting chemical that is routinely detected in > 90% of Americans, promotes experimental asthma in mice. The association of prenatal BPA exposure and wheeze has not been evaluated in humans. OBJECTIVE We examined the relationship between prenatal BPA exposure and wheeze in early childhood. METHODS We(More)
Exposure to environmental tobacco smoke (ETS) is a major cause of morbidity and mortality among U.S. children. Despite African-American children's having a lower reported exposure to tobacco compared to whites, they suffer disproportionately from tobacco-related illnesses and have higher levels of serum cotinine than white children. The goal of this study(More)
PURPOSE Exposure to environmental tobacco smoke (ETS) leads to molecular damage in the form of DNA adducts. While lung cancer risk is higher among African Americans compared to White Americans, a few studies have tested for racial differences in DNA adducts among children exposed to ETS. The purpose of this study was to test whether African American(More)
Manumycin inhibited mRNA expression of several genes associated with proinflammatory responses including IL-1 beta, IL-6, and TLR8. Among the genes upregulated in response to manumycin, HMOX1, gene for heme oxigenase 1, showed the highest mRNA induction. Conclusions: We assume from our study that manumycin and asukamycin represent potent inhibitors of IL-1(More)
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