Robert S Fogle

  • Citations Per Year
Learn More
The interaction between CXCR4 on the surface of tumor cells and CXCL12 in the stroma is believed to contribute to tumor cell survival and protection against drug treatment. Inhibition of stromal survival signals by CXCR4 antagonists has been reported to render tumor cells more sensitive to chemotherapy, but little is known about potential synergy with(More)
We previously surveyed the expression of endosialin/ CD248/TEM-1 by immunohistochemistry in human clinical specimens of sarcomas and documented expression in tumor cells, stromal cells and vasculature. In the present study, we completed a retrospective analysis of the diagnostic reports available for these same samples in order to identify high-grade and(More)
Globins, such as hemoglobin (Hb) and myoglobin (Mb), have gained attention for their ability to reduce nitrite (NO2(-)) to nitric oxide (NO). The molecular interactions that regulate this chemistry are not fully elucidated, therefore we address this issue by investigating one part of the active site that may control this reaction. Here, the effects of the(More)
Hypocrellin B (Hyp B), a perylenequinone naturally present in Hypocrella bambusae, is commonly used to treat a variety of diseases. Its versatile role in different biomedical applications necessitates a thorough investigation of its interaction with different biomolecules, particularly enzymes. To address this need, the binding mode of Hyp B to myoglobin(More)
  • 1