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Institute of Medicine. The members of the Committee responsible for the report were chosen for their special competencies and with regard for appropriate balance. This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National v ERRATUM p. 9, Secti~n 3.2, 3d(More)
Preface This synthesis summarizes the findings of the Global Natural Disaster Risk Hotspots project. The Hotspots project generated a global disaster risk assessment and a set of more localized or hazard-specific case studies. The synthesis draws primarily from the results of the global assessment. Full details on the data, methods and results of the global(More)
In A Vast Machine, Paul Edwards documents the evolution of a broad scientific field that began with the curiosity of a few 19th-century explorers and scholars and now spans a worldwide community of scientists, engineers, and other specialists working with huge quantities of data, immensely complex computer models, and many sophisticated instruments and(More)
To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid arthritis (cases) and 20,169 controls of European descent, followed by replication in an independent set of 6,768 rheumatoid arthritis cases and 8,806 controls. Of 34 SNPs(More)
The genetic architectures of common, complex diseases are largely uncharacterized. We modeled the genetic architecture underlying genome-wide association study (GWAS) data for rheumatoid arthritis and developed a new method using polygenic risk-score analyses to infer the total liability-scale variance explained by associated GWAS SNPs. Using this method,(More)
To discover new rheumatoid arthritis (RA) risk loci, we systematically examined 370 SNPs from 179 independent loci with P < 0.001 in a published meta-analysis of RA genome-wide association studies (GWAS) of 3,393 cases and 12,462 controls. We used Gene Relationships Across Implicated Loci (GRAIL), a computational method that applies statistical text mining(More)
iii "It is almost a definition of a gentleman to say that he is one who never inflicts pain." expecting my best. He gave me this opportunity and support to perform research. He gave me invaluable guidance and advice when I felt things were going wrong. His expectations and faith in my capabilities were driving forces to break through difficulties during(More)
Established in 1999, the Global Advisory Committee on Vaccine Safety advises the World Health Organization (WHO) on vaccine-related safety issues and enables WHO to respond promptly, efficiently, and with scientific rigor to issues of vaccine safety with potential global importance. The committee also assesses the implications of vaccine safety for practice(More)
video and hardcoPy Archival videos of the presentations from this session are available through Aspen Global Change Institute's website, www.agci.org. Hardcopy versions of the report are also available on a cost of reproduction basis. Contact AGCI for more information. Publications of AGCI are available on-line in cooperation with the Global Change Research(More)
Data Science Journal are simultaneously publishing " Toward Implementation of the Global Earth Observation System of Systems Data Sharing Principles. " The paper is a collaborative, interdisciplinary product of a number of authors who participated in the Group on Earth Observations (GEO) Task DA-06-01 on furthering the practical application of the agreed(More)