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Correlations between spike trains can strongly modulate neuronal activity and affect the ability of neurons to encode information. Neurons integrate inputs from thousands of afferents. Similarly, a number of experimental techniques are designed to record pooled cell activity. We review and generalize a number of previous results that show how correlations… (More)

Depletion of synaptic neurotransmitter vesicles induces a form of short term depression in synapses throughout the nervous system. This plasticity affects how synapses filter presynaptic spike trains. The filtering properties of short term depression are often studied using a deterministic synapse model that predicts the mean synaptic response to a… (More)

Networks of model neurons with balanced recurrent excitation and inhibition produce irregular and asynchronous spiking activity. We extend the analysis of balanced networks to include the known dependence of connection probability on the spatial separation between neurons. In the continuum limit we derive that stable, balanced firing rate solutions require… (More)

The fact that the eigenvalues of the family of matrices A(t) do not determine the stability of non-autonomous differential equations x = A(t)x is well known. This point is often illustrated using examples in which the matrices A(t) have constant eigenvalues with negative real part, but the solutions of the corresponding differential equation grow in time.… (More)

Correlations between neuronal spike trains affect network dynamics and population coding. Overlapping afferent populations and correlations between presynaptic spike trains introduce correlations between the inputs to downstream cells. To understand network activity and population coding, it is therefore important to understand how these input correlations… (More)

- Robert Rosenbaum, Jonathan E Rubin, Brent Doiron
- Journal of neurophysiology
- 2013

Correlated neuronal activity is an important feature in many neural codes, a neural correlate of a variety of cognitive states, as well as a signature of several disease states in the nervous system. The cellular and circuit mechanics of neural correlations is a vibrant area of research. Synapses throughout the cortex exhibit a form of short-term depression… (More)

- Robert Rosenbaum, Jonathan Rubin, Brent Doiron
- 2012

Correlated neuronal activity is an important feature in many neural codes, a neural correlate of a variety of cognitive states, as well as a signature of several disease states in the nervous system. The cellular and circuit mechanics of neural correlations is a vibrant area of research. Synapses throughout the cortex exhibit a form of short term depression… (More)

- Brent Doiron, Ashok Litwin-Kumar, Robert Rosenbaum, Gabriel K Ocker, Krešimir Josić
- Nature neuroscience
- 2016

Simultaneous recordings from large neural populations are becoming increasingly common. An important feature of population activity is the trial-to-trial correlated fluctuation of spike train outputs from recorded neuron pairs. Similar to the firing rate of single neurons, correlated activity can be modulated by a number of factors, from changes in arousal… (More)

High frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a widely used treatment for Parkinson's disease, but its effects on neural activity in basal ganglia circuits are not fully understood. DBS increases the excitation of STN efferents yet decouples STN spiking patterns from the spiking patterns of STN synaptic targets. We propose… (More)

Keywords Multi-stage programming, program generation, staged interpreters We demonstrate MetaOCaml [2, 6] as a tool that can be used to obtain efficient implementations for domain-specific languages (DSLs).