Robert Rader

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The advancements of proteomics technologies have led to a rapid increase in the number, size and rate at which datasets are generated. Managing and extracting valuable information from such datasets requires the use of data management platforms and computational approaches. We have developed the MAss SPECTRometry Analysis System (MASPECTRAS), a platform for(More)
Since its introduction quantitative real-time polymerase chain reaction (qPCR) has become the standard method for quantification of gene expression. Its high sensitivity, large dynamic range, and accuracy led to the development of numerous applications with an increasing number of samples to be analyzed. Data analysis consists of a number of steps, which(More)
Symptoms of childhood attention-deficit/hyperactivity disorder affect cognitive, academic, behavioral, emotional, social, and developmental functioning. Attention-deficit/hyperactivity disorder is the most commonly diagnosed neurodevelopmental disorder in children and adolescents. An estimated 2 to 16 percent of school-aged children have been diagnosed with(More)
Structural data from crystallographic analyses contain a vast amount of information on protein-protein contacts. Knowledge on protein-protein interactions is essential for understanding many processes in living cells. The methods to investigate these interactions range from genetics to biophysics, crystallography, bioinformatics and computer modeling. Also(More)
A phase difference technique for measuring true volume flow rate has been developed. The concept utilizes the phase difference from unequal transit times between bursts of ultrasonic energy transmitted simultaneously against and with the blood flow. A theoretical analysis reveals that the volume flow rate sensitivity (V/ml/sec) for a point crystal(More)
Recent advances in genomic sequencing have enabled the use of genome sequencing in standard biological and biotechnological research projects. The challenge is how to integrate the large amount of data in order to gain novel biological insights. One way to leverage sequence data is to use genome-scale metabolic models. We have therefore designed and(More)
Common carotid blood flow (CCBF) and respiratory water loss (RWL) were measured in dogs resting at ambient temperatures between 25 and 50 degrees C, during hypothalamic heating, and during light and heavy exercise at ambient temperatures of 25 and 35 degrees C. In resting dogs, CCBF varied with the level of RWL. Elevations in CCBF and RWL occurred within(More)