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OBJECTIVE This study evaluated the ability of the incretin mimetic exenatide (exendin-4) to improve glycemic control in patients with type 2 diabetes failing maximally effective doses of a sulfonylurea as monotherapy. RESEARCH DESIGN AND METHODS This was a triple-blind, placebo-controlled, 30-week study conducted at 101 sites in the U.S. After a 4-week,(More)
1 Overview BURG is a program that generates a fast tree parser using BURS (Bottom-Up Rewrite System) technology. It accepts a cost-augmented tree grammar and emits a C program that discovers in linear time an optimal parse of trees in the language described by the grammar. BURG has been used to construct fast optimal instruction selectors for use in code(More)
1 R ecent research has shown that adi-pose tissue is not simply an inert storage depot for lipids but is also an important endocrine organ that plays a key role in the integration of endocrine, metabolic, and inflammatory signals for the control of energy homeostasis. The adipocyte has been shown to secrete a variety of bioactive proteins into the(More)
BACKGROUND New treatments for type 2 diabetes mellitus are needed to retain insulin-glucose coupling and lower the risk of weight gain and hypoglycaemia. We aimed to investigate the safety and efficacy of liraglutide as monotherapy for this disorder. METHODS In a double-blind, double-dummy, active-control, parallel-group study, 746 patients with early(More)
The University of Washington illustrating compiler (UWPI) automatically illustrates the data structures used in simple programs written in a subset of Pascal<supscrpt>2</supscrpt>. A UWPI user submits a program to UWPI, and can then watch a graphical display show time varying illustrations of the data structures and program source code. UWPI uses the(More)
To achieve high performance in uniprocessor RISC systems, compilers must perform both register allocation to reduce memory references and instruction scheduling to avoid pipeline hazards. Compilers that separate the two functions should perform poorly on uniprocessor RISCS that support multi-cycle operations, particularly on computation-intensive workloads.(More)
Although feast and famine cycles illustrate that remodelling of adipose tissue in response to fluctuations in nutrient availability is essential for maintaining metabolic homeostasis, the underlying mechanisms remain poorly understood. Here we identify fibroblast growth factor 1 (FGF1) as a critical transducer in this process in mice, and link its(More)
OBJECTIVE Canagliflozin, a sodium glucose cotransporter (SGLT) 2 inhibitor, is also a low-potency SGLT1 inhibitor. This study tested the hypothesis that intestinal canagliflozin levels postdose are sufficiently high to transiently inhibit intestinal SGLT1, thereby delaying intestinal glucose absorption. RESEARCH DESIGN AND METHODS This two-period,(More)
Marion is a retargetable code generator system designed specifically for RISCS. Each code generator is built from a machine description that includes code selection and code scheduling information in a concise and readable format. The description language is designed to be easy to use, yet rich enough to support a broad range of RISCS. We have used Marion(More)