Robert Price

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We propose an approach to recommendation systems that optimizes over possible sets of recommended alternatives in a decision-theoretic manner. Our approach selects the alternative set that maximizes the expected valuation of the user’s choice from the recommended set. The set-based optimization explicitly recognizes the opportunity for passing residual(More)
The inclusion of a small amount of fine particle excipient in a carrier-based dry powder inhalation system is a well researched technique to improve formulation performance and is employed in the pharmaceutical industry. The removal of intrinsic fines from a lactose carrier has been found to decrease formulation performance, whereas adding fines of many(More)
This work is concerned with the synthesis and evaluation of integrated communication systems constructed specifically to perform in the presence of channel disturbances of the form encountered in multipathpropagation. In the communication system considered, information is conveyed from source to user by encoding it into electrical symbols at the transmitter(More)
Purpose. To obtain a quantitative assessment of the cohesive and adhesive force balance within dry powder inhaler formulations. Methods. The atomic force microscope (AFM) colloid probe technique was used to measure the adhesive and cohesive force characteristics of dry powder systems containing an active component (budesonide, salbutamol sulphate) and(More)
The relationship between drug/lactose ratio and aerosolisation performance of conventional carrier based formulations was investigated using the twin stage impinger. A dose range of approximately 10-450 microg of drug in a 50 mg lactose carrier formulation was studied. Statistical differences in both the fine particle dose and fine particle fraction were(More)
Genetic linkage studies in C3H/HeJ (C3H) and C57BL/6J (B6) mice identified several chromosomal locations or quantitative trait loci (QTL) linked to femoral volumetric bone mineral density (vBMD). From QTL identified on chromosomes (chr) 1, 4, 6, 13, and 18, five congenic mouse strains were developed. In each of these mice, genomic DNA from the QTL region of(More)
To investigate the role of in situ generated fine excipient particles on the fluidization and aerosolization properties of dry powder inhaler (DPI) formulations. Carrier based DPI formulations were prepared under low and high shear blending. Powder rheometery was utilized to measure bulk powder properties in a consolidated and aerated state. Powder(More)