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Overlapping and Distinct Roles of Aspergillus fumigatus UDP-glucose 4-Epimerases in Galactose Metabolism and the Synthesis of Galactose-containing Cell Wall Polysaccharides*
TLDR
This study is the first survey of glucose epimerases in A. fumigatus and contributes to the understanding of the role of these enzymes in metabolism and cell wall synthesis.
The Fungal Exopolysaccharide Galactosaminogalactan Mediates Virulence by Enhancing Resistance to Neutrophil Extracellular Traps
TLDR
The enhanced virulence of the overexpression strain of A. nidulans was associated with increased resistance to NADPH oxidase-dependent neutrophil extracellular traps in vitro, and was not observed in neutropenic mice or mice deficient in NADPH-oxidase that are unable to form NETs.
Deacetylation of Fungal Exopolysaccharide Mediates Adhesion and Biofilm Formation
TLDR
The production of cationic, deacetylated exopolysaccharides is a strategy used by both fungi and bacteria for biofilm formation and is established as a molecular mechanism of adhesion in which GAG interacts via charge-charge interactions to bind to both fungal hyphae and other substrates.
An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens.
TLDR
By combining sub-lethal concentrations of the known antifungals fluconazole, caspofungin, amphotericin B, terbinafine, benomyl, and cyprodinil with ∼3,600 compounds in diverse fungal species, this work generated a deep reservoir of chemical-chemical interactions termed the Antifungal Combinations Matrix (ACM), which highlighted that clofazimine exhibits efficacy as a combination agent against multiple fungi.
Microbial glycoside hydrolases as antibiofilm agents with cross-kingdom activity
TLDR
It is demonstrated that glycoside hydrolases derived from the opportunistic fungus Aspergillus fumigatus and Gram-negative bacterium Pseudomonas aeruginosa can be exploited to disrupt preformed fungal biofilms and reduce virulence.
Microbial glycoside hydrolases as antibiofilm agents with cross-kingdom activity
TLDR
It is demonstrated that glycoside hydrolases derived from the opportunistic fungus Aspergillus fumigatus and Gram-negative bacterium Pseudomonas aeruginosa can be exploited to disrupt pre-formed fungal biofilms and reduce virulence.
Cives romani in marmoris arte periti: the Classical World and the Renewal of the Cloister Model in 13th century Rome
An introduction of the cloister in Rome starts in the 12th century (Tre Fontane, S. Lorenzo fuori le mura, S. Cecilia in Trastevere), but it’s only in the 13th century that we find a systematic usage
Picturing the Founder. A New Reading of the Stories of St. Benedict in the Lower Church of Sacro Speco at Subiaco.
The frescoes in the lower church of the Sacro Speco at Subiaco closed the complex architectural history which during the 13th century, from the time of Pope Innocent III (1198–1216), saw the growth
The Lunette with St. Thomas Becket at the Sacro Speco in Subiaco: An Unexpected Presence?
The painting with St. Thomas Becket, St. Stephen and St. Nicholas of Bari that decorates one of the lunettes in the so-called lower church at the Sacro Speco in Subiaco is an enigma from an