Robert P. Hof

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The severity of myocardial infarction (MI) and its functional consequences are difficult to assess in small animals. We searched for criteria to achieve such an assessment in rabbits 1 week after MI. Thirteen large mongrel rabbits (3-4 kg) were anesthetized with pentobarbitone for ligating a branch of the circumflex coronary artery and 7 rabbits were(More)
  • R P Hof
  • The American journal of cardiology
  • 1987
Cardiodepressant and vasodilator effects of PN 200-110 (isradipine) were investigated in anesthetized open-chest rabbits and compared with those of nifedipine, diltiazem or placebo. In order to eliminate compensatory reflexes that may mask negative inotropic and chronotropic effects of blood pressure-lowering agents, the animals were vagotomized and(More)
BRL34915 (BRL) is a vasodilator with a novel structure. Its mechanism of action, its effects on depolarization-induced and receptor-mediated blood vessel contraction, and its hemodynamic effects were investigated. In the rat portal vein, BRL inhibited spontaneous mechanical activity [IC50 0.013 +/- 0.001 microM (mean +/- SEM) for (-)-BRL], the initial(More)
The hemodynamic effects of PY 108-068 (PY), a new benzoxadiazolyle dihydropyridine derivative with calcium antagonistic effects on vascular smooth muscle, were investigated in chloralose--urethane-anesthetized open-chest cats. Regional blood flow was measured with tracer microspheres. PY lowered blood pressure and increased cardiac output similarly to(More)
Critical success factors in solid organ and vascular transplantation are the assessment of graft status/viability as well as stringent monitoring of transplant recipients, preferentially using noninvasive techniques. This review addresses the application of magnetic resonance imaging (MRI) and spectroscopy (MRS) in the field of transplantation. The first(More)
Arteriovenous (AV) shunt vessels connect arterioles directly to the venous side. These vessels play a role in thermoregulation and in the pathophysiology of migraine. Tracer microspheres are excellent tools to study drug effects on AV anastomoses. Microspheres with a diameter of 15 microns are unable to pass through capillary vessels, but they readily cross(More)
OBJECTIVE The new immunomodulator 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol hydrochloride (FTY720) lowers the peripheral lymphocyte count (PLC) by inducing migration of circulating lymphocytes to secondary lymphoid organs. This effect is dose-dependent at low (up to 0.1 mg/kg per day) doses in rats. We investigated the correlation between PLC and(More)
The effects of the new inotropic agent, SDZ 218-135 [(+)-(S)-4-[3-(4-diphenyl-methyl-1-piperazinyl)-2-hydroxy-propyl]-6-(2-hydroxyethyl)-5-methyl-1,2,4-triazolo-[1,5-a]pyrimidin-7(4E)-one], were investigated using in vitro and in vivo techniques. In isolated rat atria, SDZ 218-135 elicited a dose-dependent increase in contractile force (+50% at 10 µM),(More)